RT Journal Article
SR Electronic
T1 The actin regulator profilin 1 is functionally associated with the mammalian centrosome
JF Life Science Alliance
JO Life Sci. Alliance
FD Life Science Alliance LLC
SP e202000655
DO 10.26508/lsa.202000655
VO 4
IS 1
A1 Nejedlá, Michaela
A1 Klebanovych, Anastasiya
A1 Sulimenko, Vadym
A1 Sulimenko, Tetyana
A1 Dráberová, Eduarda
A1 Dráber, Pavel
A1 Karlsson, Roger
YR 2021
UL http://www.life-science-alliance.org/content/4/1/e202000655.abstract
AB Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation.