RT Journal Article SR Electronic T1 The actin regulator profilin 1 is functionally associated with the mammalian centrosome JF Life Science Alliance JO Life Sci. Alliance FD Life Science Alliance LLC SP e202000655 DO 10.26508/lsa.202000655 VO 4 IS 1 A1 Nejedlá, Michaela A1 Klebanovych, Anastasiya A1 Sulimenko, Vadym A1 Sulimenko, Tetyana A1 Dráberová, Eduarda A1 Dráber, Pavel A1 Karlsson, Roger YR 2021 UL http://www.life-science-alliance.org/content/4/1/e202000655.abstract AB Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation.