PT  - JOURNAL ARTICLE
AU  - Nejedlá, Michaela
AU  - Klebanovych, Anastasiya
AU  - Sulimenko, Vadym
AU  - Sulimenko, Tetyana
AU  - Dráberová, Eduarda
AU  - Dráber, Pavel
AU  - Karlsson, Roger
TI  - The actin regulator profilin 1 is functionally associated with the mammalian centrosome
AID  - 10.26508/lsa.202000655
DP  - 2021 Jan 01
TA  - Life Science Alliance
PG  - e202000655
VI  - 4
IP  - 1
4099  - https://www.life-science-alliance.org/content/4/1/e202000655.short
4100  - https://www.life-science-alliance.org/content/4/1/e202000655.full
SO  - Life Sci. Alliance2021 Jan 01; 4
AB  - Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation.