PT  - JOURNAL ARTICLE
AU  - Nazia Abbasi
AU  - Tianyun Long
AU  - Yuxin Li
AU  - Brian A Yee
AU  - Benjamin S Cho
AU  - Juan E Hernandez
AU  - Evelyn Ma
AU  - Parth R Patel
AU  - Debashis Sahoo
AU  - Ibrahim M Sayed
AU  - Nissi Varki
AU  - Soumita Das
AU  - Pradipta Ghosh
AU  - Gene W Yeo
AU  - Wendy Jia Men Huang
TI  - DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis
AID  - 10.26508/lsa.202000772
DP  - 2020 Oct 01
TA  - Life Science Alliance
PG  - e202000772
VI  - 3
IP  - 10
4099  - https://www.life-science-alliance.org/content/3/10/e202000772.short
4100  - https://www.life-science-alliance.org/content/3/10/e202000772.full
SO  - Life Sci. Alliance2020 Oct 01; 3
AB  - Tumorigenesis in different segments of the intestinal tract involves tissue-specific oncogenic drivers. In the colon, complement component 3 (C3) activation is a major contributor to inflammation and malignancies. By contrast, tumorigenesis in the small intestine involves fatty acid–binding protein 1 (FABP1). However, little is known of the upstream mechanisms driving their expressions in different segments of the intestinal tract. Here, we report that the RNA-binding protein DDX5 binds to the mRNA transcripts of C3 and Fabp1 to augment their expressions posttranscriptionally. Knocking out DDX5 in epithelial cells protected mice from intestinal tumorigenesis and dextran sodium sulfate (DSS)–induced colitis. Identification of DDX5 as a common upstream regulator of tissue-specific oncogenic molecules provides an excellent therapeutic target for intestinal diseases.