RT Journal Article
SR Electronic
T1 Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality
JF Life Science Alliance
JO Life Sci. Alliance
FD Life Science Alliance LLC
SP e202000817
DO 10.26508/lsa.202000817
VO 3
IS 10
A1 Hong, Mun-Gwan
A1 Dodig-Crnković, Tea
A1 Chen, Xu
A1 Drobin, Kimi
A1 Lee, Woojoo
A1 Wang, Yunzhang
A1 Edfors, Fredrik
A1 Kotol, David
A1 Thomas, Cecilia Engel
A1 Sjöberg, Ronald
A1 Odeberg, Jacob
A1 Hamsten, Anders
A1 Silveira, Angela
A1 Hall, Per
A1 Nilsson, Peter
A1 Pawitan, Yudi
A1 Uhlén, Mathias
A1 Pedersen, Nancy L
A1 Hägg, Sara
A1 Magnusson, Patrik KE
A1 Schwenk, Jochen M
YR 2020
UL http://www.life-science-alliance.org/content/3/10/e202000817.abstract
AB Despite recognizing aging as a common risk factor of many human diseases, little is known about its molecular traits. To identify age-associated proteins circulating in human blood, we screened 156 individuals aged 50–92 using exploratory and multiplexed affinity proteomics assays. Profiling eight additional study sets (N = 3,987), performing antibody validation, and conducting a meta-analysis revealed a consistent age association (P = 6.61 × 10−6) for circulating histidine-rich glycoprotein (HRG). Sequence variants of HRG influenced how the protein was recognized in the immunoassays. Indeed, only the HRG profiles affected by rs9898 were associated with age and predicted the risk of mortality (HR = 1.25 per SD; 95% CI = 1.12–1.39; P = 6.45 × 10−5) during a follow-up period of 8.5 yr after blood sampling (IQR = 7.7–9.3 yr). Our affinity proteomics analysis found associations between the particular molecular traits of circulating HRG with age and all-cause mortality. The distinct profiles of this multipurpose protein could serve as an accessible and informative indicator of the physiological processes related to biological aging.