TY - JOUR T1 - IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis JF - Life Science Alliance JO - Life Sci. Alliance DO - 10.26508/lsa.202000688 VL - 3 IS - 6 SP - e202000688 AU - Jérémie D Goldstein AU - Esen Y Bassoy AU - Assunta Caruso AU - Jennifer Palomo AU - Emiliana Rodriguez AU - Sylvain Lemeille AU - Cem Gabay Y1 - 2020/06/01 UR - https://www.life-science-alliance.org/content/3/6/e202000688.abstract N2 - IL-36R signaling plays an important role in the pathogenesis of psoriasis. We ought to assess the specific function of IL-36R in keratinocytes for the pathology of Aldara-induced psoriasis-like dermatitis. Il36rΔK mice presenting deletion of IL-36R in keratinocytes were similarly resistant to Aldara-induced ear inflammation as Il36r−/− mice, but acanthosis was only prevented in Il36r−/− mice. FACS analysis revealed that IL-36R signaling in keratinocytes is mandatory for early neutrophil infiltration in Aldara-treated ears. RNASeq and qRT-PCR experiments demonstrated the crucial role of IL-36R signaling in keratinocytes for induction of IL-23, IL-17, and IL-22 at early time points. Taken together, our results demonstrate that IL-36R signaling in keratinocytes plays a major role in the induction of Aldara-induced psoriasis-like dermatitis by triggering early production of IL-23/IL-17/IL-22 cytokines and neutrophil infiltration. ER -