PT  - JOURNAL ARTICLE
AU  - Jérémie D Goldstein
AU  - Esen Y Bassoy
AU  - Assunta Caruso
AU  - Jennifer Palomo
AU  - Emiliana Rodriguez
AU  - Sylvain Lemeille
AU  - Cem Gabay
TI  - IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis
AID  - 10.26508/lsa.202000688
DP  - 2020 Jun 01
TA  - Life Science Alliance
PG  - e202000688
VI  - 3
IP  - 6
4099  - https://www.life-science-alliance.org/content/3/6/e202000688.short
4100  - https://www.life-science-alliance.org/content/3/6/e202000688.full
SO  - Life Sci. Alliance2020 Jun 01; 3
AB  - IL-36R signaling plays an important role in the pathogenesis of psoriasis. We ought to assess the specific function of IL-36R in keratinocytes for the pathology of Aldara-induced psoriasis-like dermatitis. Il36rΔK mice presenting deletion of IL-36R in keratinocytes were similarly resistant to Aldara-induced ear inflammation as Il36r−/− mice, but acanthosis was only prevented in Il36r−/− mice. FACS analysis revealed that IL-36R signaling in keratinocytes is mandatory for early neutrophil infiltration in Aldara-treated ears. RNASeq and qRT-PCR experiments demonstrated the crucial role of IL-36R signaling in keratinocytes for induction of IL-23, IL-17, and IL-22 at early time points. Taken together, our results demonstrate that IL-36R signaling in keratinocytes plays a major role in the induction of Aldara-induced psoriasis-like dermatitis by triggering early production of IL-23/IL-17/IL-22 cytokines and neutrophil infiltration.