RT Journal Article
SR Electronic
T1 Virus-induced transposable element expression up-regulation in human and mouse host cells
JF Life Science Alliance
JO Life Sci. Alliance
FD Life Science Alliance LLC
SP e201900536
DO 10.26508/lsa.201900536
VO 3
IS 2
A1 Marissa G Macchietto
A1 Ryan A Langlois
A1 Steven S Shen
YR 2020
UL https://www.life-science-alliance.org/content/3/2/e201900536.abstract
AB Virus–host cell interactions initiate a host cell–defensive response during virus infection. How transposable elements in the host cell respond to viral stress at the molecular level remains largely unclear. By reanalyzing next generation sequencing data sets from dozens of virus infection studies from the Gene Expression Omnibus database, we found that genome-wide transposon expression up-regulation in host cells occurs near antiviral response genes and exists in all studies regardless of virus, species, and host cell tissue types. Some transposons were found to be up-regulated almost immediately upon infection and before increases in virus replication and significant increases in interferon β expression. These findings indicate that transposon up-regulation is a common phenomenon during virus infection in human and mouse and that early up-regulated transposons are part of the first wave response during virus infection.