RT Journal Article
SR Electronic
T1 Conservation of cell-intrinsic immune responses in diverse nonhuman primate species
JF Life Science Alliance
JO Life Sci. Alliance
FD Life Science Alliance LLC
SP e201900495
DO 10.26508/lsa.201900495
VO 2
IS 5
A1 Jenna M Gaska
A1 Lance Parsons
A1 Metodi Balev
A1 Ann Cirincione
A1 Wei Wang
A1 Robert E Schwartz
A1 Alexander Ploss
YR 2019
UL https://www.life-science-alliance.org/content/2/5/e201900495.abstract
AB Differences in immune responses across species can contribute to the varying permissivity of species to the same viral pathogen. Understanding how our closest evolutionary relatives, nonhuman primates (NHPs), confront pathogens and how these responses have evolved over time could shed light on host range barriers, especially for zoonotic infections. Here, we analyzed cell-intrinsic immunity of primary cells from the broadest panel of NHP species interrogated to date, including humans, great apes, and Old and New World monkeys. Our analysis of their transcriptomes after poly(I:C) transfection revealed conservation in the functional consequences of their response. In mapping reads to either the human or the species-specific genomes, we observed that with the current state of NHP annotations, the percent of reads assigned to a genetic feature was largely similar regardless of the method. Together, these data provide a baseline for the cell-intrinsic responses elicited by a potent immune stimulus across multiple NHP donors, including endangered species, and serve as a resource for refining and furthering the existing annotations of NHP genomes.