RT Journal Article
SR Electronic
T1 The miRNA <em>bantam</em> regulates growth and tumorigenesis by repressing the cell cycle regulator <em>tribbles</em>
JF Life Science Alliance
JO Life Sci. Alliance
FD Life Science Alliance LLC
SP e201900381
DO 10.26508/lsa.201900381
VO 2
IS 4
A1 Gerlach, Stephan U
A1 Sander, Moritz
A1 Song, Shilin
A1 Herranz, Héctor
YR 2019
UL http://www.life-science-alliance.org/content/2/4/e201900381.abstract
AB One of the fundamental issues in biology is understanding how organ size is controlled. Tissue growth has to be carefully regulated to generate well-functioning organs, and defects in growth control can result in tumor formation. The Hippo signaling pathway is a universal growth regulator and has been implicated in cancer. In Drosophila, the Hippo pathway acts through the miRNA bantam to regulate cell proliferation and apoptosis. Even though the bantam targets regulating apoptosis have been determined, the target genes controlling proliferation have not been identified thus far. In this study, we identify the gene tribbles as a direct bantam target gene. Tribbles limits cell proliferation by suppressing G2/M transition. We show that tribbles regulation by bantam is central in controlling tissue growth and tumorigenesis. We expand our study to other cell cycle regulators and show that deregulated G2/M transition can collaborate with oncogene activation driving tumor formation.