@article {Rushinge201800218, author = {Gabrielle V Rushing and Asa A Brockman and Madelyn K Bollig and Nalin Leelatian and Bret C Mobley and Jonathan M Irish and Kevin C Ess and Cary Fu and Rebecca A Ihrie}, title = {Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis}, volume = {2}, number = {2}, elocation-id = {e201800218}, year = {2019}, doi = {10.26508/lsa.201800218}, publisher = {Life Science Alliance}, abstract = {Neural stem/progenitor cells (NSPCs) of the ventricular{\textendash}subventricular zone (V-SVZ) are candidate cells of origin for many brain tumors. However, whether NSPCs in different locations within the V-SVZ differ in susceptibility to tumorigenic mutations is unknown. Here, single-cell measurements of signal transduction intermediates in the mechanistic target of rapamycin complex 1 (mTORC1) pathway reveal that ventral NSPCs have higher levels of signaling than dorsal NSPCs. These features are linked with differences in mTORC1-driven disease severity: introduction of a pathognomonic Tsc2 mutation only results in formation of tumor-like masses from the ventral V-SVZ. We propose a direct link between location-dependent intrinsic growth properties imbued by mTORC1 and predisposition to tumor development.}, URL = {https://www.life-science-alliance.org/content/2/2/e201800218}, eprint = {https://www.life-science-alliance.org/content/2/2/e201800218.full.pdf}, journal = {Life Science Alliance} }