TY - JOUR T1 - The BMP2/4 ortholog Dpp can function as an inter-organ signal that regulates developmental timing JF - Life Science Alliance JO - Life Sci. Alliance DO - 10.26508/lsa.201800216 VL - 1 IS - 6 SP - e201800216 AU - Linda Setiawan AU - Xueyang Pan AU - Alexis L Woods AU - Michael B O'Connor AU - Iswar K Hariharan Y1 - 2018/12/01 UR - https://www.life-science-alliance.org/content/1/6/e201800216.abstract N2 - Developmental transitions are often triggered by a neuroendocrine axis and can be contingent upon multiple organs achieving sufficient growth and maturation. How the neurodendocrine axis senses the size and maturity of peripheral organs is not known. In Drosophila larvae, metamorphosis is triggered by a sharp increase in the level of the steroid hormone ecdysone, secreted by the prothoracic gland (PG). Here, we show that the BMP2/4 ortholog Dpp can function as a systemic signal to regulate developmental timing. Dpp from peripheral tissues, mostly imaginal discs, can reach the PG and inhibit ecdysone biosynthesis. As the discs grow, reduced Dpp signaling in the PG is observed, consistent with the possibility that Dpp functions in a checkpoint mechanism that prevents metamorphosis when growth is insufficient. Indeed, upon starvation early in the third larval instar, reducing Dpp signaling in the PG abrogates the critical-weight checkpoint which normally prevents pupariation under these conditions. We suggest that increased local trapping of morphogen within tissues as they grow would reduce circulating levels and hence provide a systemic readout of their growth status. ER -