TY - JOUR T1 - Identification of <em>Plasmodium</em> GAPDH epitopes for generation of antibodies that inhibit malaria infection JF - Life Science Alliance JO - Life Sci. Alliance DO - 10.26508/lsa.201800111 VL - 1 IS - 5 SP - e201800111 AU - Sung-Jae Cha AU - Kyle Jarrod McLean AU - Marcelo Jacobs-Lorena Y1 - 2018/10/01 UR - https://www.life-science-alliance.org/content/1/5/e201800111.abstract N2 - Plasmodium sporozoite liver infection is an essential step for parasite development in its mammalian host. Previously, we used a phage display library to identify mimotope peptides that bind to Kupffer cells and competitively inhibit sporozoite–Kupffer cell interaction. These peptides led to the identification of a Kupffer cell receptor—CD68—and a Plasmodium sporozoite ligand—GAPDH—that are required for sporozoite traversal of Kupffer cells and subsequent infection of hepatocytes. Here, we report that the C-terminal end of Plasmodium GAPDH interacts with the Kupffer CD68 receptor, and identify two epitopes within this region as candidate antigens for the development of antibodies that inhibit Plasmodium infection. ER -