RT Journal Article SR Electronic T1 Dynamic m6A methylation facilitates mRNA triaging to stress granules JF Life Science Alliance JO Life Sci. Alliance FD Life Science Alliance LLC SP e201800113 DO 10.26508/lsa.201800113 VO 1 IS 4 A1 Maximilian Anders A1 Irina Chelysheva A1 Ingrid Goebel A1 Timo Trenkner A1 Jun Zhou A1 Yuanhui Mao A1 Silvia Verzini A1 Shu-Bing Qian A1 Zoya Ignatova YR 2018 UL https://www.life-science-alliance.org/content/1/4/e201800113.abstract AB Reversible post-transcriptional modifications on messenger RNA emerge as prevalent phenomena in RNA metabolism. The most abundant among them is N6-methyladenosine (m6A) which is pivotal for RNA metabolism and function; its role in stress response remains elusive. We have discovered that in response to oxidative stress, transcripts are additionally m6A modified in their 5′ vicinity. Distinct from that of the translationally active mRNAs, this methylation pattern provides a selective mechanism for triaging mRNAs from the translatable pool to stress-induced stress granules. These stress-induced newly methylated sites are selectively recognized by the YTH domain family 3 (YTHDF3) “reader” protein, thereby revealing a new role for YTHDF3 in shaping the selectivity of stress response. Our findings describe a previously unappreciated function for RNA m6A modification in oxidative-stress response and expand the breadth of physiological roles of m6A.