PT  - JOURNAL ARTICLE
AU  - Aala A Abulfaraj
AU  - Kiruthiga Mariappan
AU  - Jean Bigeard
AU  - Prabhu Manickam
AU  - Ikram Blilou
AU  - Xiujie Guo
AU  - Salim Al-Babili
AU  - Delphine Pflieger
AU  - Heribert Hirt
AU  - Naganand Rayapuram
TI  - The <em>Arabidopsis</em> homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity
AID  - 10.26508/lsa.201800046
DP  - 2018 May 01
TA  - Life Science Alliance
PG  - e201800046
VI  - 1
IP  - 2
4099  - https://www.life-science-alliance.org/content/1/2/e201800046.short
4100  - https://www.life-science-alliance.org/content/1/2/e201800046.full
SO  - Life Sci. Alliance2018 May 01; 1
AB  - Mammalian Ras-GTPase–activating protein SH3-domain–binding proteins (G3BPs) are a highly conserved family of RNA-binding proteins that link kinase receptor-mediated signaling to RNA metabolism. Mammalian G3BP1 is a multifunctional protein that functions in viral immunity. Here, we show that the Arabidopsis thaliana homolog of human G3BP1 negatively regulates plant immunity. Arabidopsis g3bp1 mutants showed enhanced resistance to the virulent bacterial pathogen Pseudomonas syringae pv. tomato. Pathogen resistance was mediated in Atg3bp1 mutants by altered stomatal and apoplastic immunity. Atg3bp1 mutants restricted pathogen entry into stomates showing insensitivity to bacterial coronatine–mediated stomatal reopening. AtG3BP1 was identified as a negative regulator of defense responses, which correlated with moderate up-regulation of salicylic acid biosynthesis and signaling without growth penalty.