Genomics & Functional Genomics
Re-annotation of eight Drosophila genomesUsing a well-annotated genome to inform the annotation of genomes in a phylogeny.
A carnivorous plant genetic map: pitcher/insect-capture QTL on a genetic linkage map of SarraceniaThis study presents the first genetic map for a carnivorous plant, mapping 64 QTLs in Sarracenia to provide the genetic basis for differences between the pitfall and lobster-trap insect-capture strategies.
Small RNA-Seq reveals novel miRNAs shaping the transcriptomic identity of rat brain structuresSmall RNA-Seq of the rat central nervous system reveals known and novel miRNAs specifically regulated in brain structures and correlated with the expression of their predicted target genes, suggesting a critical role in the transcriptomic identity of brain structures.
RNase E cleavage shapes the transcriptome of Rhodobacter sphaeroides and strongly impacts phototrophic growthThis study identifies the cleavage sites of the endoribonuclease RNase E in the Rhodobacter sphaeroides transcriptome and demonstrates its effect on oxidative stress resistance and phototrophic growth.
Distinctive features of lincRNA gene expression suggest widespread RNA-independent functionsCombining single-cell RNA-seq of mouse ESCs and NPCs, lincRNA gene deletions, conditional RNA depletion, and nuclear exosome profiling distinguishes RNA-dependent and RNA-independent lincRNA gene activities.
Role of Cnot6l in maternal mRNA turnoverMice lacking Cnot6l, a deadenylase component of the CCR4–NOT complex, are viable, but females have ∼40% smaller litters. Cnot6l is a maternal-effect gene acting in maternal mRNA degradation.
Pervasive allele-specific regulation on RNA decay in hybrid miceUsing a F1 hybrid mouse system, this study globally investigates the effects of cis-regulatory divergence on RNA decay in mammals and reveals the evolutionary roles of RNA decay regulation.