Genomics & Functional Genomics
Growth-rate-dependent and nutrient-specific gene expression resource allocation in fission yeastDuring growth on nitrogen sources, growth-rate-correlated gene expression is a trade-off between the stress and growth programmes, whereas medium-specific gene expression reflects metabolic states.
pSATdb: a database of mitochondrial common, polymorphic, and unique microsatellitesThe polymorphic microSATellites database (pSATdb) provides information on common, polymorphic, and unique mitochondrial microsatellites.
Human BRCA pathogenic variants were originated during recent human historyEvolutionary origin of pathogenic variants in human BRCA1 and BRCA2.
Cap analysis of gene expression reveals alternative promoter usage in a rat model of hypertensionCap analysis of gene expression (CAGE) tag sequencing from left ventricles of a rat model of hypertension identifies genes that use alternative promoters in a disease condition.
Retinoblastoma protein regulates carcinogen susceptibility at heterochromatic cancer driver lociThe retinoblastoma protein regulates mutagenic potential via control of UV-induced DNA lesion acquisition, thus revealing novel mechanisms that contribute to its tumor suppressor capabilities.
Mammalian splicing divergence is shaped by drift, buffering in trans, and a scaling lawThis study globally investigates the allelic splicing pattern in multiple tissues of an F1 hybrid mouse and reveals the underlying driving forces shaping such tissue-dependent splicing divergence.
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprintingThis study shows that the generation of human long-lived plasma cells requires blood antibody secreting cells to undergo epigenetic and transcriptional reprogramming in response to the bone marrow microniche to become apoptosis resistant and survive to secrete antibodies for a lifetime.
CNVs with adaptive potential in Rangifer tarandus: genome architecture and new annotated assemblyNext-generation sequencing of three caribou ecotypes aligned to a new annotated genome assembly revealed divergent CNVs, including genes with annotations in line with adaptation.
HERVH-derived lncRNAs negatively regulate chromatin targeting and remodeling mediated by CHD7Mutations in CHD7 are diagnostic for human CHARGE syndrome. RNAs expressed from the HERVH repeats modulate CHD7 function providing one mechanism for regulation of differentiation of pluripotent cells.
OrtSuite: from genomes to prediction of microbial interactions within targeted ecosystem processesOrtSuite predicts synergistic species interactions using the genomic potential of microbial communities