Genomics & Functional Genomics
Z-flipon variants reveal the many roles of Z-DNA and Z-RNA in health and diseaseZ-DNABERT uses the transformer algorithm to map genomic Z-DNA. We validate the approach using chemical footprinting data from live cells. We show the utility of the approach by mapping the Z-flipons discovered to Mendelian disease variants and various quantitative traits.
Gapless provides combined scaffolding, gap filling, and assembly correction with long readsgapless is a new tool for combined execution of correction, scaffolding and gap filling using PacBio or Oxford Nanopore reads.
Recursive splicing discovery using lariats in total RNA sequencingUsing a stringent approach to map lariat reads, this study provides evidence for recursive splicing in a broader range of intron sizes than previously reported and details a new location for recursive splicing at the distal end of exons.
Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brainPleiotropic consequences of deletion of SERF in mice reveals biological functions in cell growth and development and supports the existence of biological modifiers of amyloid polymorphisms in the brain.
Small vault RNA1-2 modulates expression of cell membrane proteins through nascent RNA silencingDicer-dependent small non-coding vault RNA1-2 employs nascent RNA silencing to modulate the expression of a group of genes associated with membrane function.
Multidimensional conservation analysis decodes the expression of conserved long noncoding RNAsThe authors demonstrate the transcriptional codes that govern the expression of conserved long noncoding RNAs through multi-dimensional conservation analysis.
arfA antisense RNA regulates MscL excretory activityBacteria coordinate how they respond to translation and osmotic stress by using antisense RNA crosstalk between the genes involved in the respective stress response pathways.
Regulatory de novo mutations underlying intellectual disabilityThis study provides suggestive evidence that the de novo mutations in fetal brain-specific enhancers play role in the aetiology of intellectual disability.
New algorithms for accurate and efficient de novo genome assembly from long DNA sequencing readsInnovative algorithmic approaches were used to perform assembly of complex genomes across the tree of life, from long DNA sequencing data.
Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteriaWhole-genome sequencing is used to discover novel potential mechanisms of antimicrobial resistance and mobile genetic elements in lactic acid bacteria and bifidobacteria from the agro-food chain.