Evolution
- Gametic specialization of centromeric histone paralogs in Drosophila virilis
Somatic and germline centromeric functions could differ because of different chromatin environments in male and female gametes versus somatic cells. We show that two different centromeric histone paralogs are alternately retained in male versus female gametes in many Drosophila species.
- Phylo-geo-network and haplogroup analysis of 611 novel coronavirus (SARS-CoV-2) genomes from India
Evolution of SARS-CoV-2 in India across 51 haplogroups based on 152 parsimony informative sites revealed B6 and B1 (Pangolin) and A2a (Covidex) as the most prevalent lineage and clade, respectively.
- Incipient sympatric speciation in wild barley caused by geological-edaphic divergence
Sympatric speciation is still contentious but here based on genome-wide analysis; we show incipient sympatric speciation of an emerging new wild barley species from Hordeum spontaneum, the progenitor of all cultivated barleys at “Evolution Plateau” (EP), Upper Galilee, Israel.
- An evolutionary approach to systematic discovery of novel deubiquitinases, applied to Legionella
The analysis of the relationships between different deubiquitinase classes leads to the definition of an aromatic “gatekeeper” motif that distinguishes DUBs from other cysteine proteases and helps to predict new bacterial DUBs.
- Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain
Comparative analysis reveals adaptive evolution of bat IFITMs and a naturally polymorphic site within the conserved CD225 domain that affects S-palmitoylation and antiviral function of bat IFITM3.
- Endogenous RNAi pathway evolutionarily shapes the destiny of the antisense lncRNAs transcriptome
A genome-wide comparative analysis of “cryptic” aslncRNAs decay in RNAi-capable and RNAi-deficient budding yeasts suggests an evolutionary contribution of RNAi in shaping the aslncRNAs transcriptome.
- The impact of poly-A microsatellite heterologies in meiotic recombination
Meiosis strongly influences the transmission and evolution of heterozygous poly-A repeats as measured experimentally in a large collection of single recombination products in a human hotspot.
- Worldwide genetic variation of the IGHV and TRBV immune receptor gene families in humans
This article presents a comprehensive study of the IGHV and TRBV gene families in a globally diverse sample of humans and shows that the two gene families exhibit starkly different patterns of variation.
- Evolution of gene expression levels in the male reproductive organs of Anopheles mosquitoes
Expression patterns of transcripts in reproductive tissues reveal the phylogeny of the An. gambiae complex and are indicative of molecular function, transcription regulatory networks, and protein–protein interaction networks.
- Re-annotation of eight Drosophila genomes
Using a well-annotated genome to inform the annotation of genomes in a phylogeny.