Evolution
Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and DrosophilaCRISPR knockout of msl-2 and epigenome analyses in Anopheles reveal that X chromosome dosage compensation in mosquitos and Drosophila is achieved by two different molecular mechanisms.
Hierarchical dinucleotide distribution in genome along evolution and its effect on chromatin packingIt describes how hierarchical CpG distribution on the genomes of species change in the evolution and the correlation with the chromatin structure.
Gametic specialization of centromeric histone paralogs in Drosophila virilisSomatic and germline centromeric functions could differ because of different chromatin environments in male and female gametes versus somatic cells. We show that two different centromeric histone paralogs are alternately retained in male versus female gametes in many Drosophila species.
Phylo-geo-network and haplogroup analysis of 611 novel coronavirus (SARS-CoV-2) genomes from IndiaEvolution of SARS-CoV-2 in India across 51 haplogroups based on 152 parsimony informative sites revealed B6 and B1 (Pangolin) and A2a (Covidex) as the most prevalent lineage and clade, respectively.
Incipient sympatric speciation in wild barley caused by geological-edaphic divergenceSympatric speciation is still contentious but here based on genome-wide analysis; we show incipient sympatric speciation of an emerging new wild barley species from Hordeum spontaneum, the progenitor of all cultivated barleys at “Evolution Plateau” (EP), Upper Galilee, Israel.
An evolutionary approach to systematic discovery of novel deubiquitinases, applied to LegionellaThe analysis of the relationships between different deubiquitinase classes leads to the definition of an aromatic “gatekeeper” motif that distinguishes DUBs from other cysteine proteases and helps to predict new bacterial DUBs.
Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domainComparative analysis reveals adaptive evolution of bat IFITMs and a naturally polymorphic site within the conserved CD225 domain that affects S-palmitoylation and antiviral function of bat IFITM3.
Endogenous RNAi pathway evolutionarily shapes the destiny of the antisense lncRNAs transcriptomeA genome-wide comparative analysis of “cryptic” aslncRNAs decay in RNAi-capable and RNAi-deficient budding yeasts suggests an evolutionary contribution of RNAi in shaping the aslncRNAs transcriptome.
The impact of poly-A microsatellite heterologies in meiotic recombinationMeiosis strongly influences the transmission and evolution of heterozygous poly-A repeats as measured experimentally in a large collection of single recombination products in a human hotspot.
Worldwide genetic variation of the IGHV and TRBV immune receptor gene families in humansThis article presents a comprehensive study of the IGHV and TRBV gene families in a globally diverse sample of humans and shows that the two gene families exhibit starkly different patterns of variation.