Evolution
ETV2 induces endothelial, but not hematopoietic, lineage specification in birdsETV2, a master regulator of blood and vessel development in mammals, is deleted in bird genomes, and exogenous ETV2 induces endothelial lineage specification in nascent chicken mesoderm.
FERM domain–containing proteins are active components of the cell nucleusThe information we gathered from the literature reveals that FERM domain proteins perform important and diverse functions not only in the cytoplasm, but also in the cell nucleus.
The origin, evolution, and molecular diversity of the chemokine systemExtensive phylogenetic analysis of chemokine signalling molecules reveals the origin and evolution of canonical and non-canonical components, shedding light on the evolution of this complex system.
Yolk-deprived Caenorhabditis elegans secure brood size at the expense of competitive fitnessMany egg-laying species lower fecundity when yolk is in short supply, but not C. elegans. They still produce abundant offspring, yet of decreased quality.
Branch point strength controls species-specific CAMK2B alternative splicing and regulates LTPA mechanism that contributes to species-specific alternative splicing leading to increased coding capacity of primate genomes is presented and functionality for CamK2β splicing addressed.
Convergent evolution and horizontal gene transfer in Arctic Ocean microalgaeThe Arctic Ocean stands apart from other oceans. Using multiple genomes and transcriptomes from cultured and environmental sources, we found distinct genetic modifications in Arctic microalgae consistent with biogeographically constrained trait selectivity as an adaptive force in algal evolution.
Pandemic Vibrio cholerae acquired competitive traits from an environmental Vibrio speciesPandemic-associated Vibrio cholerae interbacterial defense genes were likely acquired through competition with and subsequent gene transfer from the fish pathogen Vibrio anguillarum.
C-to-U RNA deamination is the driving force accelerating SARS-CoV-2 evolutionThe authors propose that the host-mediated C-to-U RNA editing event, which is also affected by the RNA structure, is the driving force that accelerates SARS-CoV-2 mutation and evolution.
Tandemly repeated NBPF HOR copies (Olduvai triplets): Possible impact on human brain evolutionThe human genome, unlike the genomes of other primates, contains tandemly organized higher order NBPF structures that represent a link to the development of their cognitive abilities.
Molecular insights into high-altitude adaption and acclimatisation of Aporrectodea caliginosaA megabase genome assembly for Aporrectodea caliginosa is presented with transcriptomic and SNP-based evidence for acclimatisation and adaption to extreme weather conditions found at high altitude.