Development
Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturationMaternal gestational circulating microRNAs, predictive of adverse infant outcomes, including growth deficits, following prenatal alcohol exposure, contribute to placental pathology by impairing the EMT pathway in trophoblasts.
Redundant and nonredundant organismal functions of EPS15 and EPS15L1This study unveils a redundant function for the endocytic proteins Eps15 and Eps15L1 in mouse embryo development and erythropoiesis, and a unique nonredundant role for Eps15L1 in the nervous system.
Polycomb and Notch signaling regulate cell proliferation potential during Caenorhabditis elegans life cycleCaenorhabditis elegans lineage is invariant between animals. By challenging cell fate in differentiated worms, an unexpected role of Polycomb and Notch signaling in the control of cell proliferation was uncovered, suggesting that the lineage is more flexible than believed.
Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with IHO1. Its N-terminal region forms a Pleckstrin homology domain, while its C-terminal region is interacting with MEI4.
The BMP2/4 ortholog Dpp can function as an inter-organ signal that regulates developmental timingIncreased local trapping of morphogens within tissues as they grow would reduce circulating levels and can therefore provide a systemic readout of the status of their growth and maturation.
Transposon silencing in the Drosophila female germline is essential for genome stability in progeny embryosSuppression of transposons by the Piwi-interacting RNA biogenesis factor Vasa in the supporting nurse cells is essential to prevent their accumulation in the developing oocyte, ensuring proper Drosophila embryonic development.
Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cordThis work demonstrates a role for the Wilms tumor protein Wt1 in the specification of neurons that are involved in the control of locomotion.
Role of Cnot6l in maternal mRNA turnoverMice lacking Cnot6l, a deadenylase component of the CCR4–NOT complex, are viable, but females have ∼40% smaller litters. Cnot6l is a maternal-effect gene acting in maternal mRNA degradation.