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Development

  • Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturation
    Open Access
    Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturation

    Alexander M Tseng, Amanda H Mahnke, Alan B Wells, Nihal A Salem, Andrea M Allan, Victoria HJ Roberts, Natali Newman, Nicole AR Walter, Christopher D Kroenke, Kathleen A Grant, Lisa K Akison, Karen M Moritz, Christina D Chambers, Rajesh C Miranda, Collaborative Initiative on Fetal Alcohol Spectrum Disorders

    Alexander M Tseng ... Collaborative Initiative on Fetal Alcohol Spectrum Disorders

    Published 4 March 2019

    Maternal gestational circulating microRNAs, predictive of adverse infant outcomes, including growth deficits, following prenatal alcohol exposure, contribute to placental pathology by impairing the EMT pathway in trophoblasts.

  • Redundant and nonredundant organismal functions of EPS15 and EPS15L1
    Open Access
    Redundant and nonredundant organismal functions of EPS15 and EPS15L1

    Cinzia Milesi, Paola Alberici, Benedetta Pozzi, Amanda Oldani, Galina V Beznoussenko, Andrea Raimondi, Blanche Ekalle Soppo, Stefania Amodio, Giusi Caldieri, Maria Grazia Malabarba, Giovanni Bertalot, Stefano Confalonieri, Dario Parazzoli, Alexander A Mironov, Carlo Tacchetti, Pier Paolo Di Fiore, Sara Sigismund, Nina Offenhäuser

    Cinzia Milesi ... Nina Offenhäuser

    Published 28 January 2019

    This study unveils a redundant function for the endocytic proteins Eps15 and Eps15L1 in mouse embryo development and erythropoiesis, and a unique nonredundant role for Eps15L1 in the nervous system.

  • Polycomb and Notch signaling regulate cell proliferation potential during <em>Caenorhabditis elegans</em> life cycle
    Open Access
    Polycomb and Notch signaling regulate cell proliferation potential during Caenorhabditis elegans life cycle

    Francesca Coraggio, Ringo Püschel, Alisha Marti, Peter Meister

    Francesca Coraggio ... Peter Meister

    Published 26 December 2018

    Caenorhabditis elegans lineage is invariant between animals. By challenging cell fate in differentiated worms, an unexpected role of Polycomb and Notch signaling in the control of cell proliferation was uncovered, suggesting that the lineage is more flexible than believed.

  • Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4
    Open Access
    Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4

    Rajeev Kumar, Cecilia Oliver, Christine Brun, Ariadna B Juarez-Martinez, Yara Tarabay, Jan Kadlec, Bernard de Massy

    Rajeev Kumar ... Bernard de Massy

    Published 10 December 2018

    Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with IHO1. Its N-terminal region forms a Pleckstrin homology domain, while its C-terminal region is interacting with MEI4.

  • The BMP2/4 ortholog Dpp can function as an inter-organ signal that regulates developmental timing
    Open Access
    The BMP2/4 ortholog Dpp can function as an inter-organ signal that regulates developmental timing

    Linda Setiawan, Xueyang Pan, Alexis L Woods, Michael B O'Connor, Iswar K Hariharan

    Linda Setiawan ... Iswar K Hariharan

    Published 19 November 2018

    Increased local trapping of morphogens within tissues as they grow would reduce circulating levels and can therefore provide a systemic readout of the status of their growth and maturation.

  • Transposon silencing in the <em>Drosophila</em> female germline is essential for genome stability in progeny embryos
    Open Access
    Transposon silencing in the Drosophila female germline is essential for genome stability in progeny embryos

    Zeljko Durdevic, Ramesh S Pillai, Anne Ephrussi

    Zeljko Durdevic ... Anne Ephrussi

    Published 17 September 2018

    Suppression of transposons by the Piwi-interacting RNA biogenesis factor Vasa in the supporting nurse cells is essential to prevent their accumulation in the developing oocyte, ensuring proper Drosophila embryonic development.

  • Neuron-specific inactivation of <em>Wt1</em> alters locomotion in mice and changes interneuron composition in the spinal cord
    Open Access
    Neuron-specific inactivation of Wt1 alters locomotion in mice and changes interneuron composition in the spinal cord

    Danny Schnerwitzki, Sharn Perry, Anna Ivanova, Fabio V Caixeta, Paul Cramer, Sven Günther, Kathrin Weber, Atieh Tafreshiha, Lore Becker, Ingrid L Vargas Panesso, Thomas Klopstock, Martin Hrabe de Angelis, Manuela Schmidt, Klas Kullander, Christoph Englert

    Danny Schnerwitzki ... Christoph Englert

    Published 16 August 2018

    This work demonstrates a role for the Wilms tumor protein Wt1 in the specification of neurons that are involved in the control of locomotion.

  • Role of <em>Cnot6l</em> in maternal mRNA turnover
    Open Access
    Role of Cnot6l in maternal mRNA turnover

    Filip Horvat, Helena Fulka, Radek Jankele, Radek Malik, Ma Jun, Katerina Solcova, Radislav Sedlacek, Kristian Vlahovicek, Richard M Schultz, Petr Svoboda

    Filip Horvat ... Petr Svoboda

    Published 16 July 2018

    Mice lacking Cnot6l, a deadenylase component of the CCR4–NOT complex, are viable, but females have ∼40% smaller litters. Cnot6l is a maternal-effect gene acting in maternal mRNA degradation.

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