Development
The hypoxia-response pathway modulates RAS/MAPK–mediated cell fate decisions in Caenorhabditis elegansAtmospheric oxygen levels modulate the RAS/MAPK signaling pathway in the nematode Caenorhabditis elegans through a cross-talk between the DELTA/NOTCH and hypoxia signaling pathways. These mechanisms may permit the animals to adapt their development to changes in the environment.
CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growthInhibition of the CXXC5–DVL interaction is a potential therapeutic strategy for height enhancement of children with growth retardation.
ROS amplification drives mouse spermatogonial stem cell self-renewalAlthough reactive oxygen species (ROS) are required for spermatogonial stem cell (SSC) self-renewal, the mechanism has remained unknown. We show that SSC self-renewal signals activate MAPK14/MAPK7 pathway to induce nuclear translocation of BCL6B and activation of NOX1.
Intra-individual methylomics detects the impact of early-life adversityThis study shows that methylation profile changes across time in the same individual distinguish a stressful experience from typical infancy, providing a potential predictive marker of vulnerability to disease.
Sequence and expression levels of circular RNAs in progenitor cell types during mouse corticogenesisThis study identifies circular RNAs (circRNAs) in specific cell types of the developing mammalian cortex. This resource addresses the complexity and potential significance of this elusive class of transcripts.
Epidermal development requires ninein for spindle orientation and cortical microtubule organizationIn the epidermis, ninein affects spindle orientation of progenitor cells, as well as cortical microtubule organization, desmosome assembly, and lamellar body secretion in differentiating cells.
Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesisPer-cell quantification of mTORC1 signaling activity in neural stem/progenitor cells reveals differential signaling, proliferative, and tumor-forming capability between dorsal and ventral cells within a single niche.
let-7 coordinates the transition to adulthood through a single primary and four secondary targetsAlthough miRNAs may act through regulation of numerous targets, this study shows that the Caenorhabditis elegans let-7 miRNA promotes the juvenile-to-adult transition through repression of LIN41 alone, thereby activating four LIN41 targets that function in pairs to execute distinct developmental functions.
Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturationMaternal gestational circulating microRNAs, predictive of adverse infant outcomes, including growth deficits, following prenatal alcohol exposure, contribute to placental pathology by impairing the EMT pathway in trophoblasts.
Redundant and nonredundant organismal functions of EPS15 and EPS15L1This study unveils a redundant function for the endocytic proteins Eps15 and Eps15L1 in mouse embryo development and erythropoiesis, and a unique nonredundant role for Eps15L1 in the nervous system.