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Development

  • The miRNA <em>bantam</em> regulates growth and tumorigenesis by repressing the cell cycle regulator <em>tribbles</em>
    Open Access
    The miRNA bantam regulates growth and tumorigenesis by repressing the cell cycle regulator tribbles

    Stephan U Gerlach, Moritz Sander, Shilin Song, Héctor Herranz

    Stephan U Gerlach ... Héctor Herranz

    Published 22 July 2019

    This work identifies the cell cycle regulator tribbles as a target of the miRNA bantam involved in the growth regulatory and oncogenic functions of bantam in Drosophila epithelia.

  • Opposing functions of F-BAR proteins in neuronal membrane protrusion, tubule formation, and neurite outgrowth
    Open Access
    Opposing functions of F-BAR proteins in neuronal membrane protrusion, tubule formation, and neurite outgrowth

    Kendra L Taylor, Russell J Taylor, Karl E Richters, Brandon Huynh, Justin Carrington, Maeve E McDermott, Rebecca L Wilson, Erik W Dent

    Kendra L Taylor ... Erik W Dent

    Published 3 June 2019

    Neurite formation is a fundamental antecedent to axon and dendrite formation, but the mechanisms that underlie this important process are poorly characterized. Here, we demonstrate that two F-BAR proteins, CIP4 and FBP17, have opposing functions in early cortical neuron development.

  • The hypoxia-response pathway modulates RAS/MAPK–mediated cell fate decisions in <em>Caenorhabditis elegans</em>
    Open Access
    The hypoxia-response pathway modulates RAS/MAPK–mediated cell fate decisions in Caenorhabditis elegans

    Sabrina Maxeiner, Judith Grolleman, Tobias Schmid, Jan Kammenga, Alex Hajnal

    Sabrina Maxeiner ... Alex Hajnal

    Published 24 May 2019

    Atmospheric oxygen levels modulate the RAS/MAPK signaling pathway in the nematode Caenorhabditis elegans through a cross-talk between the DELTA/NOTCH and hypoxia signaling pathways. These mechanisms may permit the animals to adapt their development to changes in the environment.

  • CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth
    Open Access
    CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth

    Sehee Choi, Hyun-Yi Kim, Pu-Hyeon Cha, Seol Hwa Seo, Chulho Lee, Yejoo Choi, Wookjin Shin, Yunseok Heo, Gyoonhee Han, Weontae Lee, Kang-Yell Choi

    Sehee Choi ... Kang-Yell Choi

    Published 10 April 2019

    Inhibition of the CXXC5–DVL interaction is a potential therapeutic strategy for height enhancement of children with growth retardation.

  • ROS amplification drives mouse spermatogonial stem cell self-renewal
    Open Access
    ROS amplification drives mouse spermatogonial stem cell self-renewal

    Hiroko Morimoto, Mito Kanastu-Shinohara, Narumi Ogonuki, Satoshi Kamimura, Atsuo Ogura, Chihiro Yabe-Nishimura, Yoshifumi Mori, Takeshi Morimoto, Satoshi Watanabe, Kinya Otsu, Takuya Yamamoto, Takashi Shinohara

    Hiroko Morimoto ... Takashi Shinohara

    Published 2 April 2019

    Although reactive oxygen species (ROS) are required for spermatogonial stem cell (SSC) self-renewal, the mechanism has remained unknown. We show that SSC self-renewal signals activate MAPK14/MAPK7 pathway to induce nuclear translocation of BCL6B and activation of NOX1.

  • Intra-individual methylomics detects the impact of early-life adversity
    Open Access
    Intra-individual methylomics detects the impact of early-life adversity

    Shan Jiang, Noriko Kamei, Jessica L Bolton, Xinyi Ma, Hal S Stern, Tallie Z Baram, Ali Mortazavi

    Shan Jiang ... Ali Mortazavi

    Published 1 April 2019

    This study shows that methylation profile changes across time in the same individual distinguish a stressful experience from typical infancy, providing a potential predictive marker of vulnerability to disease.

  • Sequence and expression levels of circular RNAs in progenitor cell types during mouse corticogenesis
    Open Access
    Sequence and expression levels of circular RNAs in progenitor cell types during mouse corticogenesis

    Martina Dori, Leila Haj Abdullah Alieh, Daniel Cavalli, Simone Massalini, Mathias Lesche, Andreas Dahl, Federico Calegari

    Martina Dori ... Federico Calegari

    Published 29 March 2019

    This study identifies circular RNAs (circRNAs) in specific cell types of the developing mammalian cortex. This resource addresses the complexity and potential significance of this elusive class of transcripts.

  • Epidermal development requires ninein for spindle orientation and cortical microtubule organization
    Open Access
    Epidermal development requires ninein for spindle orientation and cortical microtubule organization

    Nicolas Lecland, Chiung-Yueh Hsu, Cécile Chemin, Andreas Merdes, Christiane Bierkamp

    Nicolas Lecland ... Christiane Bierkamp

    Published 28 March 2019

    In the epidermis, ninein affects spindle orientation of progenitor cells, as well as cortical microtubule organization, desmosome assembly, and lamellar body secretion in differentiating cells.

  • Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis
    Open Access
    Location-dependent maintenance of intrinsic susceptibility to mTORC1-driven tumorigenesis

    Gabrielle V Rushing, Asa A Brockman, Madelyn K Bollig, Nalin Leelatian, Bret C Mobley, Jonathan M Irish, Kevin C Ess, Cary Fu, Rebecca A Ihrie

    Gabrielle V Rushing ... Rebecca A Ihrie

    Published 25 March 2019

    Per-cell quantification of mTORC1 signaling activity in neural stem/progenitor cells reveals differential signaling, proliferative, and tumor-forming capability between dorsal and ventral cells within a single niche.

  • <em>let-7</em> coordinates the transition to adulthood through a single primary and four secondary targets
    Open Access
    let-7 coordinates the transition to adulthood through a single primary and four secondary targets

    Florian Aeschimann, Anca Neagu, Magdalene Rausch, Helge Großhans

    Florian Aeschimann ... Helge Großhans

    Published 25 March 2019

    Although miRNAs may act through regulation of numerous targets, this study shows that the Caenorhabditis elegans let-7 miRNA promotes the juvenile-to-adult transition through repression of LIN41 alone, thereby activating four LIN41 targets that function in pairs to execute distinct developmental functions.

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