Development
Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesisMaternal hyperglycemia and elevated O-GlcNAc levels perturb promoter bivalency and lead to transcriptional up-regulation of neurogenic transcription factors during embryonic neurogenesis.
Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivoCell division completes when the two daughter cells move their oldest centrosome towards the cytokinetic bridge, which is then cleaved during abscission. The GTPase, Rab11, and the centrosome protein, Pericentrin, work together to coordinate this movement.
AGO1 regulates pericentromeric regions in mouse embryonic stem cellsDepletion of AGO1 in mESCs leads to a redistribution of H3K9me3 and HP1α away from pericentromeric regions and is accompanied by an up-regulation of major satellites transcripts.
The expression of essential selenoproteins during development requires SECIS-binding protein 2–likeThis work reveals that the Sbp2 paralogue, Secisbp2-like, is required for selective selenoprotein synthesis when the function of Sbp2 is compromised.
Rbfox1 is required for myofibril development and maintaining fiber type–specific isoform expression in Drosophila musclesRbfox1 is required for the development of both fibrillar and tubular muscle fibers in adult Drosophila and interacts with Bruno1 to define fiber type–specific patterns of alternative splicing.
Poly(ADP-ribosyl)ating pathway regulates development from stem cell niche to longevity controlThe phosphorylation of poly(ADP-risobyl) glycohydrolase is involved in stem-cells differentiation, embryonic/larval development, regulation of longevity and fertility by calorie restriction.
Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrityThis study describes the the role of a nuclear pore complex protein in mammalian in skeletal muscle maintenance, repair, and function.
Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entryRESF1 supports ESC self-renewal by raising expression of transmembrane LIF receptor and key pluripotency transcription factors and increases in vitro primordial germ cell differentiation efficiency.
Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroidsExpression dynamics of basement membrane-like extracellular matrix and fibronectin regulate transitions between solid (moruloid) and cavitational (blastuloid) phenotypes of ovarian cancer spheroids.
Asymmetrical deposition and modification of histone H3 variants are essential for zygote developmentA low level of H3.1/2 deposition in the perinucleolar regions of male pronuclei in zygotes prevents accumulation of H3.1/2K27me3 modification which has detrimental effect on DNA replication.