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Development

  • Nutrient sensitive protein <em>O</em>-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis
    Open Access
    Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis

    Shama Parween, Thilina T Alawathugoda, Ashok D Prabakaran, S Thameem Dheen, Randall H Morse, Bright Starling Emerald, Suraiya A Ansari

    Shama Parween ... Suraiya A Ansari

    Published 25 April 2022

    Maternal hyperglycemia and elevated O-GlcNAc levels perturb promoter bivalency and lead to transcriptional up-regulation of neurogenic transcription factors during embryonic neurogenesis.

  • Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivo
    Open Access
    Rab11 endosomes and Pericentrin coordinate centrosome movement during pre-abscission in vivo

    Nikhila Krishnan, Maxx Swoger, Lindsay I Rathbun, Peter J Fioramonti, Judy Freshour, Michael Bates, Alison E Patteson, Heidi Hehnly

    Nikhila Krishnan ... Heidi Hehnly

    Published 18 March 2022

    Cell division completes when the two daughter cells move their oldest centrosome towards the cytokinetic bridge, which is then cleaved during abscission. The GTPase, Rab11, and the centrosome protein, Pericentrin, work together to coordinate this movement.

  • AGO1 regulates pericentromeric regions in mouse embryonic stem cells
    Open Access
    AGO1 regulates pericentromeric regions in mouse embryonic stem cells

    Madlen Müller, Tara Fäh, Moritz Schaefer, Victoria Hermes, Janina Luitz, Patrick Stalder, Rajika Arora, Richard Patryk Ngondo, Constance Ciaudo

    Madlen Müller ... Constance Ciaudo

    Published 2 March 2022

    Depletion of AGO1 in mESCs leads to a redistribution of H3K9me3 and HP1α away from pericentromeric regions and is accompanied by an up-regulation of major satellites transcripts.

  • The expression of essential selenoproteins during development requires SECIS-binding protein 2–like
    Open Access
    The expression of essential selenoproteins during development requires SECIS-binding protein 2–like

    Nora T Kiledjian, Rushvi Shah, Michael B Vetick, Paul R Copeland

    Nora T Kiledjian ... Paul R Copeland

    Published 24 February 2022

    This work reveals that the Sbp2 paralogue, Secisbp2-like, is required for selective selenoprotein synthesis when the function of Sbp2 is compromised.

  • Rbfox1 is required for myofibril development and maintaining fiber type–specific isoform expression in <em>Drosophila</em> muscles
    Open Access
    Rbfox1 is required for myofibril development and maintaining fiber type–specific isoform expression in Drosophila muscles

    Elena Nikonova, Amartya Mukherjee, Ketaki Kamble, Christiane Barz, Upendra Nongthomba, Maria L Spletter

    Elena Nikonova ... Maria L Spletter

    Published 7 January 2022

    Rbfox1 is required for the development of both fibrillar and tubular muscle fibers in adult Drosophila and interacts with Bruno1 to define fiber type–specific patterns of alternative splicing.

  • Poly(ADP-ribosyl)ating pathway regulates development from stem cell niche to longevity control
    Open Access
    Poly(ADP-ribosyl)ating pathway regulates development from stem cell niche to longevity control

    Guillaume Bordet, Elena Kotova, Alexei V Tulin

    Guillaume Bordet ... Alexei V Tulin

    Published 23 December 2021

    The phosphorylation of poly(ADP-risobyl) glycohydrolase is involved in stem-cells differentiation, embryonic/larval development, regulation of longevity and fertility by calorie restriction.

  • Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity
    Open Access
    Loss of Nup210 results in muscle repair delays and age-associated alterations in muscle integrity

    Stephen Sakuma, Ethan YS Zhu, Marcela Raices, Pan Zhang, Rabi Murad, Maximiliano A D’Angelo

    Stephen Sakuma ... Maximiliano A D’Angelo

    Published 15 December 2021

    This study describes the  the role of a nuclear pore complex protein in mammalian in skeletal muscle maintenance, repair, and function.

  • Loss of <em>Resf1</em> reduces the efficiency of embryonic stem cell self-renewal and germline entry
    Open Access
    Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entry

    Matúš Vojtek, Ian Chambers

    Matúš Vojtek ... Ian Chambers

    Published 4 October 2021

    RESF1 supports ESC self-renewal by raising expression of transmembrane LIF receptor and key pluripotency transcription factors and increases in vitro primordial germ cell differentiation efficiency.

  • Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids
    Open Access
    Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids

    Jimpi Langthasa, Purba Sarkar, Shruthi Narayanan, Rahul Bhagat, Annapurna Vadaparty, Ramray Bhat

    Jimpi Langthasa ... Ramray Bhat

    Published 10 August 2021

    Expression dynamics of basement membrane-like extracellular matrix and fibronectin regulate transitions between solid (moruloid) and cavitational (blastuloid) phenotypes of ovarian cancer spheroids.

  • Asymmetrical deposition and modification of histone H3 variants are essential for zygote development
    Open Access
    Asymmetrical deposition and modification of histone H3 variants are essential for zygote development

    Machika Kawamura, Satoshi Funaya, Kenta Sugie, Masataka G Suzuki, Fugaku Aoki

    Machika Kawamura ... Fugaku Aoki

    Published 24 June 2021

    A low level of H3.1/2 deposition in the perinucleolar regions of male pronuclei in zygotes prevents accumulation of H3.1/2K27me3 modification which has detrimental effect on DNA replication.

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