Development
Condensate-forming eIF4ET ensures adequate levels of meiotic proteins to support oocyte storageBhatia et al use female nematodes to reveal how the conserved eIF4E-transporter protein (eIF4ET) plays an unexpected role in promoting translation of cytoskeletal proteins to support days-long storage of arrested oocytes.
Deep learning models link local cellular features with whole-animal growth dynamics in zebrafishThe study introduces a deep learning-assisted approach for uncovering the intricate, real-time cross-length scale interactions between individual cells and the entire organism in a vertebrate model.
AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylationAurora kinase A regulates kinetochore function by phosphorylating HEC1 at serine 69 in mouse oocytes undergoing completion of meiosis I, contributing to SAC activation and chromosome alignment.
CLCa mediates a novel cross-talk between Wnt secretion and actin organizationThe clathrin light chain, CLCa, regulates Wnt secretion in a WLS-dependent manner. Furthermore, CLCa drives actin organization and participates in its cross-talk with Wnt signaling in mammalian cells.
Diversification of dentate gyrus granule cell subtypes is regulated by Nrg1 nuclear back-signalingThe study shows that Nrg1 nuclear signaling maintains granule cell identity and that its disruption drives acquisition of semilunar granule cell fate in the dentate gyrus.
A biallelic variant in GORASP1 causes a novel Golgipathy with glycosylation and mitotic defectsThis study identifies the first human pathogenic variant in GORASP1, the gene encoding the Golgi stacking protein GRASP65, and demonstrates its consequences on glycosylation and mitotic progression.
Trans-scale live-imaging of an E5.5 mouse embryo using incubator-type biaxial light-sheet microscopyWe achieve in-toto single-cell observation in a whole hemisphere of an E5.5 embryo for 12 h, optimizing a special microscope system, including an incubator, and refining the observation protocol.
Divergent destinies: insights into the molecular mechanisms underlying EPI and PE fate determinationThis review explores the molecular mechanisms governing epiblast and primitive endoderm fate determination during murine pre-implantation development, dissecting this lineage specification process into four stages to provide a comprehensive framework for understanding their establishment and maintenance.
ciBAR1 loss in mice causes laterality defects, pancreatic degeneration, and altered glucose toleranceciBAR1-KO mice exhibit ciliopathy phenotypes such as embryonic lethality and exocrine and endocrine pancreatic defects, indicating that ciBAR1 plays a critical role in ciliogenesis in vivo.
KAT6B is required for histone 3 lysine 9 acetylation and SOX gene expression in the developing brainHeterozygous mutations in the MYST family histone lysine acetyltransferase, KAT6B, cause intellectual disability disorders. This study identifies the histone and gene targets of KAT6B which include SOX2, a master regulator of neural stem and progenitor cells.