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Development

  • UHRF1 is essential for proper cytoplasmic architecture and function of mouse oocytes and derived embryos
    Open Access
    UHRF1 is essential for proper cytoplasmic architecture and function of mouse oocytes and derived embryos

    Shuhei Uemura, Shoji Maenohara, Kimiko Inoue, Narumi Ogonuki, Shogo Matoba, Atsuo Ogura, Mayuko Kurumizaka, Kazuo Yamagata, Jafar Sharif, Haruhiko Koseki, Koji Ueda, Motoko Unoki, Hiroyuki Sasaki

    Shuhei Uemura ... Hiroyuki Sasaki

    Published 24 May 2023

    This study shows that the UHRF1 protein, an epigenetic factor, regulates cytoplasmic proteins in oocytes independently of gene expression and ensures normal preimplantation development.

  • The CHARGE syndrome-associated protein FAM172A controls AGO2 nuclear import
    Open Access
    The CHARGE syndrome-associated protein FAM172A controls AGO2 nuclear import

    Sephora Sallis, Félix-Antoine Bérubé-Simard, Benoit Grondin, Elizabeth Leduc, Fatiha Azouz, Catherine Bélanger, Nicolas Pilon

    Sephora Sallis ... Nicolas Pilon

    Published 23 May 2023

    AGO2 has long been known to shuttle between the cytosol and the nucleus of mammalian cells and this study helps to understand how this occurs.

  • Origin and segregation of the human germline
    Open Access
    Origin and segregation of the human germline

    Aracely Castillo-Venzor, Christopher A Penfold, Michael D Morgan, Walfred WC Tang, Toshihiro Kobayashi, Frederick CK Wong, Sophie Bergmann, Erin Slatery, Thorsten E Boroviak, John C Marioni, M Azim Surani

    Aracely Castillo-Venzor ... M Azim Surani

    Published 22 May 2023

    Human primordial germ cells originate in peri-gastrulation embryos from the posterior epiblast precursors with an obligatory role for TFAP2A, which is redundant for contribution to the amnion.

  • Evaluation of genetic demultiplexing of single-cell sequencing data from model species
    Open Access
    Evaluation of genetic demultiplexing of single-cell sequencing data from model species

    Joseph F Cardiello, Alberto Joven Araus, Sarantis Giatrellis, Clement Helsens, András Simon, Nicholas D Leigh

    Joseph F Cardiello ... Nicholas D Leigh

    Published 17 May 2023

    The authors demonstrate that scRNA-seq sample pooling followed by genetics-based separation of individuals is an effective means to identify individual samples in a variety of commonly studied species.

  • Prostaglandin F2α regulates mitochondrial dynamics and mitophagy in the bovine corpus luteum
    Open Access
    Prostaglandin F2α regulates mitochondrial dynamics and mitophagy in the bovine corpus luteum

    Michele R Plewes, Emilia Przygrodzka, Corrine F Monaco, Alexandria P Snider, Jessica A Keane, Patrick D Burns, Jennifer R Wood, Andrea S Cupp, John S Davis

    Michele R Plewes ... John S Davis

    Published 15 May 2023

    This study investigates the early effects of PGF2α signaling on mitochondrial dynamics and mitophagy in bovine corpora lutea. Luteolytic mediator PGF2α, via PKC/ERK and AMPK signaling, activates mitochondrial fission and promotes PINK–Parkin mitophagy, placing mitochondria as novel targets in response to PGF2α.

  • Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain
    Open Access
    Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain

    Esther Stroo, Leen Janssen, Olga Sin, Wytse Hogewerf, Mirjam Koster, Liesbeth Harkema, Sameh A Youssef, Natalie Beschorner, Anouk HG Wolters, Bjorn Bakker, Lore Becker, Lilian Garrett, Susan Marschall, Sabine M Hoelter, Wolfgang Wurst, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Amantha Thathiah, Floris Foijer, Bart van de Sluis, Jan van Deursen, Matthias Jucker, Alain de Bruin, Ellen AA Nollen

    Esther Stroo ... Ellen AA Nollen

    Published 2 May 2023

    Pleiotropic consequences of deletion of SERF in mice reveals biological functions in cell growth and development and supports the existence of biological modifiers of amyloid polymorphisms in the brain.

  • Yolk-deprived <em>Caenorhabditis elegans</em> secure brood size at the expense of competitive fitness
    Open Access
    Yolk-deprived Caenorhabditis elegans secure brood size at the expense of competitive fitness

    Ellen Geens, Pieter Van de Walle, Francesca Caroti, Rob Jelier, Christian Steuwe, Liliane Schoofs, Liesbet Temmerman

    Ellen Geens ... Liesbet Temmerman

    Published 14 April 2023

    Many egg-laying species lower fecundity when yolk is in short supply, but not C. elegans. They still produce abundant offspring, yet of decreased quality.

  • EZH2 controls epicardial cell migration during heart development
    Open Access
    EZH2 controls epicardial cell migration during heart development

    Haobin Jiang, Lina Bai, Shen Song, Qianqian Yin, Anteng Shi, Bin Zhou, Hong Lian, Houzao Chen, Cheng-ran Xu, Yanchun Wang, Yu Nie, Shengshou Hu

    Haobin Jiang ... Shengshou Hu

    Published 10 April 2023

    EZH2 influences epicardial cell migration into the myocardium via TIMP3-dependent fine tuning of basement membrane degradation, which leads to cardiac malformations and embryonic lethality.

  • Local tissue mechanics control cardiac pacemaker cell embryonic patterning
    Open Access
    Local tissue mechanics control cardiac pacemaker cell embryonic patterning

    Trevor Henley, Julie Goudy, Marietta Easterling, Carrie Donley, Robert Wirka, Michael Bressan

    Trevor Henley ... Michael Bressan

    Published 27 March 2023

    Microenvironmental patterning during sinoatrial node morphogenesis is critical for sustaining cardiac pacemaker cell function.

  • Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes
    Open Access
    Filopodia-like protrusions of adjacent somatic cells shape the developmental potential of oocytes

    Flora Crozet, Gaëlle Letort, Rose Bulteau, Christelle Da Silva, Adrien Eichmuller, Anna Francesca Tortorelli, Joséphine Blévinal, Morgane Belle, Julien Dumont, Tristan Piolot, Aurélien Dauphin, Fanny Coulpier, Alain Chédotal, Jean-Léon Maître, Marie-Hélène Verlhac, Hugh J Clarke, Marie-Emilie Terret

    Flora Crozet ... Marie-Emilie Terret

    Published 21 March 2023

    Filopodia-like protrusions sent by the somatic cells to the oocyte play a role in the structural integrity of the germline–somatic complex, and regulate gene expression in the oocyte and thus its developmental potential and chances to produce a viable embryo.

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