Development
GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification programThis work shows that GATA transcription factors transduce the BMP signaling and, with SOX17 and TFAP2C, induce the human germ-cell fate, delineating the mechanism for human germ-cell specification.
Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectoriesUsing integrated genome-wide and phenotypic methods this study investigates four different mutant RUNX1 oncoproteins and reveals how they differentially contribute to aberrant haematopoiesis.
Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formationN-terminal Aub arginines are dispensable for primary piRNA biogenesis but essential for amplification; their symmetric dimethylation is required for germline inheritance but not for piRNA amplification.
Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouseThe vital role of the splicing factor SRRM4 in vestibular and inner hair cells of the ear is inactivation of the gene repressor REST; however, in outer hair cells, SRRM4 is dispensable for REST inactivation, which SRRM3 accomplishes independently.
MicroRNA regulation of murine trophoblast stem cell self-renewal and differentiationPost-transcriptional regulation of CDX2 and cell cycle genes by miR-290 and miR-322 clusters along with transactivation of miR-290 cluster and cyclin D1 by CDX2 equipoise trophoblast stem cell self-renewal and differentiation.
Robust production of uniform human cerebral organoids from pluripotent stem cellsBy leveraging advances in 3D stem cell culture techniques, the authors describe, characterize and validate a novel platform to efficiently generate morphologically consistent human forebrain cerebral organoids.
BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expressionOur work highlights BACH family of transcription factors as a novel regulator of angiogenesis and lymphangiogenesis during zebrafish embryonic development and tumor expansion.
Defining the expression of piRNA and transposable elements in Drosophila ovarian germline stem cells and somatic support cellsComprehensive transcriptional characterization of mRNA and small RNA in early Drosophila germline stem cells reveals novel piRNA clusters, transposon dynamics, and alternative splicing events.
Unfolded protein-independent IRE1 activation contributes to multifaceted developmental processes in ArabidopsisThe Arabidopsis unfolded protein response transducer IRE1 contributes to male gametophyte development using an alternative activation mechanism bypassing the unfolded protein-sensing domain.
Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency markerExpression of TET proteins in pluripotent cell types is visualised by epitope tagging of endogenous alleles.