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Development

  • GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program
    Open Access
    GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program

    Yoji Kojima, Chika Yamashiro, Yusuke Murase, Yukihiro Yabuta, Ikuhiro Okamoto, Chizuru Iwatani, Hideaki Tsuchiya, Masataka Nakaya, Tomoyuki Tsukiyama, Tomonori Nakamura, Takuya Yamamoto, Mitinori Saitou

    Yoji Kojima ... Mitinori Saitou

    Published 19 February 2021

    This work shows that GATA transcription factors transduce the BMP signaling and, with SOX17 and TFAP2C, induce the human germ-cell fate, delineating the mechanism for human germ-cell specification.

  • Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories
    Open Access
    Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories

    Sophie G Kellaway, Peter Keane, Benjamin Edginton-White, Kakkad Regha, Ella Kennett, Constanze Bonifer

    Sophie G Kellaway ... Constanze Bonifer

    Published 4 January 2021

    Using integrated genome-wide and phenotypic methods this study investigates four different mutant RUNX1 oncoproteins and reveals how they differentially contribute to aberrant haematopoiesis.

  • Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation
    Open Access
    Modulation of Aub–TDRD interactions elucidates piRNA amplification and germplasm formation

    Nicholas Vrettos, Manolis Maragkakis, Panagiotis Alexiou, Paraskevi Sgourdou, Fadia Ibrahim, Daniel Palmieri, Yohei Kirino, Zissimos Mourelatos

    Nicholas Vrettos ... Zissimos Mourelatos

    Published 29 December 2020

    N-terminal Aub arginines are dispensable for primary piRNA biogenesis but essential for amplification; their symmetric dimethylation is required for germline inheritance but not for piRNA amplification.

  • Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse
    Open Access
    Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse

    Yoko Nakano, Susan Wiechert, Bernd Fritzsch, Botond Bánfi

    Yoko Nakano ... Botond Bánfi

    Published 21 October 2020

    The vital role of the splicing factor SRRM4 in vestibular and inner hair cells of the ear is inactivation of the gene repressor REST; however, in outer hair cells, SRRM4 is dispensable for REST inactivation, which SRRM3 accomplishes independently.

  • MicroRNA regulation of murine trophoblast stem cell self-renewal and differentiation
    Open Access
    MicroRNA regulation of murine trophoblast stem cell self-renewal and differentiation

    Sarbani Saha, Rupasri Ain

    Sarbani Saha ... Rupasri Ain

    Published 9 September 2020

    Post-transcriptional regulation of CDX2 and cell cycle genes by miR-290 and miR-322 clusters along with transactivation of miR-290 cluster and cyclin D1 by CDX2 equipoise trophoblast stem cell self-renewal and differentiation.

  • Robust production of uniform human cerebral organoids from pluripotent stem cells
    Open Access
    Robust production of uniform human cerebral organoids from pluripotent stem cells

    Adam A Sivitilli, Jessica T Gosio, Bibaswan Ghoshal, Alesya Evstratova, Daniel Trcka, Parisa Ghiasi, J Javier Hernandez, Jean Martin Beaulieu, Jeffrey L Wrana, Liliana Attisano

    Adam A Sivitilli ... Liliana Attisano

    Published 17 April 2020

    By leveraging advances in 3D stem cell culture techniques, the authors describe, characterize and validate a novel platform to efficiently generate morphologically consistent human forebrain cerebral organoids.

  • BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression
    Open Access
    BACH family members regulate angiogenesis and lymphangiogenesis by modulating VEGFC expression

    Batya Cohen, Hanoch Tempelhof, Tal Raz, Roni Oren, Julian Nicenboim, Filip Bochner, Ron Even, Adam Jelinski, Raya Eilam, Shifra Ben-Dor, Yoseph Adaddi, Ofra Golani, Shlomi Lazar, Karina Yaniv, Michal Neeman

    Batya Cohen ... Michal Neeman

    Published 4 March 2020

    Our work highlights BACH family of transcription factors as a novel regulator of angiogenesis and lymphangiogenesis during zebrafish embryonic development and tumor expansion.

  • Defining the expression of piRNA and transposable elements in <em>Drosophila</em> ovarian germline stem cells and somatic support cells
    Open Access
    Defining the expression of piRNA and transposable elements in Drosophila ovarian germline stem cells and somatic support cells

    Benjamin Story, Xing Ma, Kazue Ishihara, Hua Li, Kathryn Hall, Allison Peak, Perera Anoja, Jungeun Park, Jeff Haug, Marco Blanchette, Ting Xie

    Benjamin Story ... Ting Xie

    Published 16 October 2019

    Comprehensive transcriptional characterization of mRNA and small RNA in early Drosophila germline stem cells reveals novel piRNA clusters, transposon dynamics, and alternative splicing events.

  • Unfolded protein-independent IRE1 activation contributes to multifaceted developmental processes in Arabidopsis
    Open Access
    Unfolded protein-independent IRE1 activation contributes to multifaceted developmental processes in Arabidopsis

    Kei-ichiro Mishiba, Yuji Iwata, Tomofumi Mochizuki, Atsushi Matsumura, Nanami Nishioka, Rikako Hirata, Nozomu Koizumi

    Kei-ichiro Mishiba ... Nozomu Koizumi

    Published 10 October 2019

    The Arabidopsis unfolded protein response transducer IRE1 contributes to male gametophyte development using an alternative activation mechanism bypassing the unfolded protein-sensing domain.

  • Endogenous epitope-tagging of <em>Tet1</em>, <em>Tet2</em> and <em>Tet3</em> identifies TET2 as a naïve pluripotency marker
    Open Access
    Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency marker

    Raphaël Pantier, Tülin Tatar, Douglas Colby, Ian Chambers

    Raphaël Pantier ... Ian Chambers

    Published 3 October 2019

    Expression of TET proteins in pluripotent cell types is visualised by epitope tagging of endogenous alleles.

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