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Development

  • Condensate-forming eIF4ET ensures adequate levels of meiotic proteins to support oocyte storage
    Open Access
    Condensate-forming eIF4ET ensures adequate levels of meiotic proteins to support oocyte storage

    Priyankaa Bhatia, Judith Tafur, Ruchi Amin, Nicole E Familiari, Kan Yaguchi, Vanna M Tran, Alec Bond, Orhan Bukulmez, Jeffrey B Woodruff

    Priyankaa Bhatia ... Jeffrey B Woodruff

    Published 29 May 2025

    Bhatia et al use female nematodes to reveal how the conserved eIF4E-transporter protein (eIF4ET) plays an unexpected role in promoting translation of cytoskeletal proteins to support days-long storage of arrested oocytes.

  • Deep learning models link local cellular features with whole-animal growth dynamics in zebrafish
    Open Access
    Deep learning models link local cellular features with whole-animal growth dynamics in zebrafish

    Shang-Ru Yang, Megan Liaw, An-Chi Wei, Chen-Hui Chen

    Shang-Ru Yang ... Chen-Hui Chen

    Published 21 May 2025

    The study introduces a deep learning-assisted approach for uncovering the intricate, real-time cross-length scale interactions between individual cells and the entire organism in a vertebrate model.

  • AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation
    Open Access
    AURKA controls oocyte spindle assembly checkpoint and chromosome alignment by HEC1 phosphorylation

    Cecilia S Blengini, Shuang Tang, Robert J Mendola, G John Garrisi, Jason E Swain, Karen Schindler

    Cecilia S Blengini ... Karen Schindler

    Published 6 May 2025

    Aurora kinase A regulates kinetochore function by phosphorylating HEC1 at serine 69 in mouse oocytes undergoing completion of meiosis I, contributing to SAC activation and chromosome alignment.

  • CLCa mediates a novel cross-talk between Wnt secretion and actin organization
    Open Access
    CLCa mediates a novel cross-talk between Wnt secretion and actin organization

    Mahak Tiwari, Mihir Dingankar, Jyoti Das, Sreelekshmi S R, Apurv Solanki, Deepa Subramanyam

    Mahak Tiwari ... Deepa Subramanyam

    Published 2 May 2025

    The clathrin light chain, CLCa, regulates Wnt secretion in a WLS-dependent manner. Furthermore, CLCa drives actin organization and participates in its cross-talk with Wnt signaling in mammalian cells.

  • Diversification of dentate gyrus granule cell subtypes is regulated by Nrg1 nuclear back-signaling
    Open Access
    Diversification of dentate gyrus granule cell subtypes is regulated by Nrg1 nuclear back-signaling

    Prithviraj Rajebhosale, Li Jiang, Haylee J Ressa, Kory R Johnson, Niraj S Desai, Alice Jone, Lorna W Role, David A Talmage

    Prithviraj Rajebhosale ... David A Talmage

    Published 25 April 2025

    The study shows that Nrg1 nuclear signaling maintains granule cell identity and that its disruption drives acquisition of semilunar granule cell fate in the dentate gyrus.

  • A biallelic variant in <em>GORASP1</em> causes a novel Golgipathy with glycosylation and mitotic defects
    Open Access
    A biallelic variant in GORASP1 causes a novel Golgipathy with glycosylation and mitotic defects

    Sophie Lebon, Arnaud Bruneel, Séverine Drunat, Alexandra Albert, Zsolt Csaba, Monique Elmaleh, Alexandra Ntorkou, Yann Ténier, François Fenaille, Pierre Gressens, Sandrine Passemard, Odile Boespflug-Tanguy, Imen Dorboz, Vincent El Ghouzzi

    Sophie Lebon ... Vincent El Ghouzzi

    Published 11 February 2025

    This study identifies the first human pathogenic variant in GORASP1, the gene encoding the Golgi stacking protein GRASP65, and demonstrates its consequences on glycosylation and mitotic progression.

  • Trans-scale live-imaging of an E5.5 mouse embryo using incubator-type biaxial light-sheet microscopy
    Open Access
    Trans-scale live-imaging of an E5.5 mouse embryo using incubator-type biaxial light-sheet microscopy

    Go Shioi, Tomonobu M Watanabe, Junichi Kaneshiro, Yusuke Azuma, Shuichi Onami

    Go Shioi ... Shuichi Onami

    Published 15 January 2025

    We achieve in-toto single-cell observation in a whole hemisphere of an E5.5 embryo for 12 h, optimizing a special microscope system, including an incubator, and refining the observation protocol.

  • Divergent destinies: insights into the molecular mechanisms underlying EPI and PE fate determination
    Open Access
    Divergent destinies: insights into the molecular mechanisms underlying EPI and PE fate determination

    Paraskevi Athanasouli, Tijs Vanhessche, Frederic Lluis

    Paraskevi Athanasouli ... Frederic Lluis

    Published 8 January 2025

    This review explores the molecular mechanisms governing epiblast and primitive endoderm fate determination during murine pre-implantation development, dissecting this lineage specification process into four stages to provide a comprehensive framework for understanding their establishment and maintenance.

  • ciBAR1 loss in mice causes laterality defects, pancreatic degeneration, and altered glucose tolerance
    Open Access
    ciBAR1 loss in mice causes laterality defects, pancreatic degeneration, and altered glucose tolerance

    Eunice N Kim, Feng-Qian Li, Ken-Ichi Takemaru

    Eunice N Kim ... Ken-Ichi Takemaru

    Published 2 December 2024

    ciBAR1-KO mice exhibit ciliopathy phenotypes such as embryonic lethality and exocrine and endocrine pancreatic defects, indicating that ciBAR1 plays a critical role in ciliogenesis in vivo.

  • KAT6B is required for histone 3 lysine 9 acetylation and SOX gene expression in the developing brain
    Open Access
    KAT6B is required for histone 3 lysine 9 acetylation and SOX gene expression in the developing brain

    Maria I Bergamasco, Waruni Abeysekera, Alexandra L Garnham, Yifang Hu, Connie SN Li-Wai-Suen, Bilal N Sheikh, Gordon K Smyth, Tim Thomas, Anne K Voss

    Maria I Bergamasco ... Anne K Voss

    Published 13 November 2024

    Heterozygous mutations in the MYST family histone lysine acetyltransferase, KAT6B, cause intellectual disability disorders. This study identifies the histone and gene targets of KAT6B which include SOX2, a master regulator of neural stem and progenitor cells.

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