Stem Cells 2022
Last updated
We are pleased to present this special collection of articles recently published in LSA highlighting some of the latest advances in stem cell research. Articles featured in the collection were published within the past 12 months and include original findings on progenitor cell regulation, intestinal stem cell clonal dynamics and breast cancer dormancy. We hope you enjoy reading this collection, and we invite you to follow LSA on Twitter (@LSAjournal). Learn more about submitting your research at https://www.life-science-alliance.org.
Analysis of clonal dynamics of intestinal stem cells supports an accelerated clonal drift upon aging, likely because of reduced adhesion of aged ISCs because of reduced canonical Wnt signaling.
This study identified and characterized four different populations of muscle progenitor cells derived from human induced pluripotent stem cells.
Depletion of AGO1 in mESCs leads to a redistribution of H3K9me3 and HP1α away from pericentromeric regions and is accompanied by an up-regulation of major satellites transcripts.
Mutations in CHD7 are diagnostic for human CHARGE syndrome. RNAs expressed from the HERVH repeats modulate CHD7 function providing one mechanism for regulation of differentiation of pluripotent cells.
A TPP1 mutation known to cause telomere shortening and bone marrow failure in humans recapitulates telomere loss but results in severe germline defects in mice without impacting murine hematopoiesis.
A signaling cascade composing M3, EphB/ephrin-B, and MEK synergizes to guide the homeostasis of intestinal epithelial cell growth and differentiation following modifications of the cholinergic intestinal niche.
Knockout of Pnkp in adult mice impairs the growth of hair follicle, spermatogonial, and neural progenitor populations.
CDH2 is required for connexin 43 (Cx43)–mediated gap junction intercellular communication between breast cancer cells and bone marrow niche cells to achieve dormancy and chemoresistance.
