Neuroscience Collection
Last updated
We invite you to take a look at our neuroscience collection of recent Life Science Alliance articles. The selected articles cover a wide range of topics and approaches from superresolution microscopy of Aβ42 to the importance of Wilms tumor suppressor gene Wt1 for neuronal circuits controlling locomotion. Read how Phelan–McDermid syndrome-associated JIP2 haploinsufficiency affects neuronal maturation, or on the role of translation rate for C9orf72 ALS/FTD, neural cell fate specification, and glioma. We hope you enjoy the collection!
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Chromatin-mediated translation dictates neural cell fate
Chd5 loss links the up-regulation of ribosomal genes to enhanced translation, causing the untimely production of a master transcription factor that unleashes stem cells and alters cell fate.
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Wt1 inactivation alters dl6 neurons and locomotion
This work demonstrates a role for the Wilms tumor protein Wt1 in the specification of neurons that are involved in the control of locomotion.
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Role of JIP2 in 22qDS iPSC neuron differentiation
Molecular and cellular profiling of patient-specific neural cell types provides suggestions for the involvement of JIP2 in the neurodevelopmental disorder Phelan–McDermid syndrome.
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Aβ42 localization at the neuronal synapse
Super-resolution microscopy reveals that Aβ42 is mainly present at the presynaptic side of the synapse.
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Poly-GR/PR interactome
Proteomics and neuropathological validation show that aberrant poly-GR/PR proteins in C9orf72 ALS/FTD bind STAU2 and ribosomes and inhibit translation.
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BACE2 brain expression and substrates
β-Site APP-cleaving enzyme 1 (BACE1) inhibition to treat Alzheimer’s disease also inhibits BACE2. This work shows BACE2 expression in the mouse brain and identifies its substrates. Increased BACE2 processing of vascular cell adhesion molecule 1 during inflammatory conditions cautions the use of current nonspecific BACE1 inhibitors in the clinic.