Virus-induced transposable element expression up-regulation in human and mouse host cells

Genome-wide transposon expression up-regulation in host cells regardless of virus, species, and host cell tissue types occurs early during viral infection and likely contributes to promoting the host innate immune response.

As you will see, the reviewers appreciate your analysis, but raise some concerns with the data/their interpretation that need to get addressed to allow publication here. All three reviewers provide constructive input on how to revise your work and we would thus like to invite you to submit such a revised version to us. Most requests can get addressed by re-analysis of existing data, still requiring major revision efforts. The reviewers also point out that your work refers to TE activation without providing data supporting this. Addressing this point with data would clearly strengthen the value of your work to others tremendously, so we would like to encourage you to include such data (eg via comparing RNA-seq and CAGE-seq data if available).
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Thank you for this interesting contribution to Life Science Alliance. We are looking forward to receiving your revised manuscript .  --High-resolut ion figure, supplement ary figure and video files uploaded as individual files: See our det ailed guidelines for preparing your product ion-ready images, ht tp://www.life-sciencealliance.org/aut hors --Summary blurb (ent er in submission syst em): A short text summarizing in a single sent ence the st udy (max. 200 charact ers including spaces). This text is used in conjunct ion wit h the tit les of papers, hence should be informat ive and complement ary to the tit le and running tit le. It should describe the cont ext and significance of the findings for a general readership; it should be writ ten in the present tense and refer to the work in the third person. Aut hor names should not be ment ioned.

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Full guidelines are available on our Inst ruct ions for Aut hors page, ht tp://www.life-sciencealliance.org/aut hors We encourage our aut hors to provide original source dat a, part icularly uncropped/-processed elect rophoret ic blot s and spreadsheet s for the main figures of the manuscript . If you would like to add source dat a, we would welcome one PDF/Excel-file per figure for this informat ion. These files will be linked online as supplement ary "Source Dat a" files. ***IMPORT ANT: It is Life Science Alliance policy that if request ed, original dat a images must be made available. Failure to provide original images upon request will result in unavoidable delays in publicat ion. Please ensure that you have access to all original microscopy and blot dat a images before submit ting your revision.*** January 3, 2020 1st Revision -Editorial Decision Thank you for submitting your revised manuscript entitled "Virus-induced transposable element expression upreulation in human and mouse host cells". As you will see, the reviewers now support publication, and we would thus be happy to publish your paper in Life Science Alliance pending final minor revisions: -Please address reviewer #2's concern by stating in the relevant section of the manuscript the rationale for using only the first read pair of paired-end reads -Please upload all figure files, including suppl. Figures, as individual files and without figure legends; the figure legends should all go into the main manuscript docx file, please -Please add callouts to Fig S7D, S9A-E, and S10 to the manuscript text If you are planning a press release on your work, please inform us immediately to allow informing our production team and scheduling a release date.
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B. MANUSCRIPT ORGANIZATION AND FORMATTING:
Full guidelines are available on our Instructions for Authors page, http://www.life-sciencealliance.org/authors We encourage our authors to provide original source data, particularly uncropped/-processed electrophoretic blots and spreadsheets for the main figures of the manuscript. If you would like to add source data, we would welcome one PDF/Excel-file per figure for this information. These files will be linked online as supplementary "Source Data" files. **Submission of a paper that does not conform to Life Science Alliance guidelines will delay the acceptance of your manuscript.** **It is Life Science Alliance policy that if requested, original data images must be made available to the editors. Failure to provide original images upon request will result in unavoidable delays in publication. Please ensure that you have access to all original data images prior to final submission.** **The license to publish form must be signed before your manuscript can be sent to production. A link to the electronic license to publish form will be sent to the corresponding author only. Please take a moment to check your funder requirements.** **Reviews, decision letters, and point-by-point responses associated with peer-review at Life Science Alliance will be published online, alongside the manuscript. If you do want to opt out of having the reviewer reports and your point-by-point responses displayed, please let us know immediately.** Thank you for your attention to these final processing requirements. Please revise and format the manuscript and upload materials within 7 days.
Thank you for this interesting contribution, we look forward to publishing your paper in Life Science Alliance. Thank you for submitting your Research Article entitled "Virus-induced transposable element expression upreulation in human and mouse host cells". It is a pleasure to let you know that your manuscript is now accepted for publication in Life Science Alliance. Congratulations on this interesting work.
The final published version of your manuscript will be deposited by us to PubMed Central upon online publication.
Your manuscript will now progress through copyediting and proofing. It is journal policy that authors provide original data upon request.
Reviews, decision letters, and point-by-point responses associated with peer-review at Life Science Alliance will be published online, alongside the manuscript. If you do want to opt out of having the reviewer reports and your point-by-point responses displayed, please let us know immediately. ***IMPORTANT: If you will be unreachable at any time, please provide us with the email address of an alternate author. Failure to respond to routine queries may lead to unavoidable delays in publication.*** Scheduling details will be available from our production department. You will receive proofs shortly before the publication date. Only essential corrections can be made at the proof stage so if there are any minor final changes you wish to make to the manuscript, please let the journal office know now.

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Authors are required to distribute freely any materials used in experiments published in Life Science Alliance. Authors are encouraged to deposit materials used in their studies to the appropriate repositories for distribution to researchers.
You can contact the journal office with any questions, contact@life-science-alliance.org Again, congratulations on a very nice paper. I hope you found the review process to be constructive and are pleased with how the manuscript was handled editorially. We look forward to future exciting submissions from your lab. Sincerely,