LSA Immunology Collection 2025
Last updated
We are pleased to present this special collection of immunology articles recently published in LSA that most interested our readers. This collection highlights the breadth of biological processes and diseases that are directly regulated by immune cells and inflammation, including T cell receptor signaling, neutrophils in tuberculosis, the gut microbiome, and responses of HIV-infected T cells to antiviral therapy. Also included are a resource on murine macrophage cell lines, as well as a review on the regulation of B cells by the CXCR4 receptor.
We hope you enjoy reading this collection, and we invite you to follow LSA on X/Twitter (@LSAjournal) and Bluesky (@LSAjournal.org). Learn more about submitting your research.
Image © 2024 Vinci et al.
This study highlights the resilience of the gut microbiome to host immune changes triggered by COVID-19 vaccination and suggest minimal, if any, impact on microbiome-mediated processes.
The HIV-1 Tat inhibitor didehydro-cortistatin A not only blocks HIV-1 transcription but also induces specific transcriptional and epigenetic changes in CD4+ T cells, promoting a tolerogenic Treg/Th2 phenotype and reducing inflammatory gene expression.
Interferon type I modulates the gene expression of inflammasome-related genes and reduces cytokine release induced by NLRP3 inflammasome activation in human macrophages in vitro.
SHIP1 plays a cell-intrinsic role in osteoclast function and development, yet skeletal growth retardation in SHIP1-deficient mice is dependent on lymphocyte-induced inflammation.
Inhibiting the ciliary protein UNC119 in primary T cells alters LCK localisation and function independently of the phosphorylation state. UNC119 also may represent a therapeutic target in T acute lymphocytic leukaemia as UNC119 inhibition reduced cancer cell growth.
This study explores the impact of breast implant surface topographies on immune responses, using analyses of periprosthetic fluids and in vitro cultures on model surface replicas, revealing that macrotextured implants significantly induce chronic-like inflammatory reactions.
ILC1 activation by the oxygen-sensitive transcription factor HIF-1α is detrimental upon acute colitis, but protects against inflammation and fibrosis during chronic colitis.
In this article, we characterised multiple murine macrophage cell models by proteomics and identified significant differences compared with bone marrow–derived macrophages.
Fixed single-cell RNA profiling identified IL-17A/F-producing γδ T cells, ILC3s, and Th17 cells, cooperative roles of M1- and M2-like macrophages, and dual roles of neutrophils during severe dengue.
This review provides an overview of the role of the C-X-C chemokine receptor type 4 (CXCR4) in B-cell development and in B cell–mediated disorders.
