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LSA Immunology Collection 2022

Last updated

21 February 2023 15:50

We are pleased to present this special collection of articles recently published in LSA highlighting some of the latest advances in immunology. Articles featured in the collection were published within the past 12 months and include original findings on COVID-19, T cell function and immune response to viral infection. We hope you enjoy reading this collection, and we invite you to follow LSA on Twitter (@LSAjournal). Learn more about submitting your research at https://www.life-science-alliance.org.


mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients
Elena Azzolini, Chiara Pozzi, Luca Germagnoli, Bianca Oresta, Nicola Carriglio, Mariella Calleri, Carlo Selmi, Maria De Santis, Silvia Finazzi, Carmelo Carlo-Stella, Alexia Bertuzzi, Francesca Motta, Angela Ceribelli, Alberto Mantovani, Fabrizio Bonelli, Maria Rescigno

Immunocompromised patients poorly respond to two doses of SARS-CoV-2 mRNA vaccines. However, an additional booster dose elicits a strong humoral and cellular immune response in these subjects.

 

Malaria abrogates O'nyong–nyong virus pathologies by restricting virus infection in nonimmune cells
Anthony Torres-Ruesta, Teck-Hui Teo, Yi-Hao Chan, Siti Naqiah Amrun, Nicholas Kim-Wah Yeo, Cheryl Yi-Pin Lee, Samantha Yee-Teng Nguee, Matthew Zirui Tay, Francois Nosten, Siew-Wai Fong, Fok-Moon Lum, Guillaume Carissimo, Laurent Renia, Lisa FP Ng

This study reveals that acute blood-stage malaria promotes resistance to ONNV infection by inducing IFNg-dependent antiviral status in human and murine nonimmune cells.


 

Integrated stress response restricts macrophage necroptosis
David E Place, Parimal Samir, RK Subbarao Malireddi, Thirumala-Devi Kanneganti

Stress inhibits necroptosis in a PERK-dependent manner via reduced RIPK1-RIPK3-MLKL signaling, showing an integral mechanistic connection between stress responses and programmed cell death.


 

Functional and metabolic fitness of human CD4+ T lymphocytes during metabolic stress
Lisa Holthaus, Virag Sharma, Daniel Brandt, Anette-Gabriele Ziegler, Martin Jastroch, Ezio Bonifacio

Human T-cell activation, expansion, and effector function is grossly impaired in conditions that combine glucose deprivation and mild mitochondrial stress.

 

Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19
Claudia Gomes, Marisol Zuniga, Kelly A Crotty, Kun Qian, Nubia Catalina Tovar, Lawrence Hsu Lin, Kimon V Argyropoulos, Robert Clancy, Peter Izmirly, Jill Buyon, David C Lee, Maria Fernanda Yasnot-Acosta, Huilin Li, Paolo Cotzia, Ana Rodriguez

COVID-19 induces high levels of autoimmune anti-DNA and anti-phosphatidylserine antibodies that are detected in some patients upon hospital admission and predict later development of severe disease.


 

Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma
Matthias M Schneider, Marc Emmenegger, Catherine K Xu, Itzel Condado Morales, Georg Meisl, Priscilla Turelli, Chryssa Zografou, Manuela R Zimmermann, Beat M Frey, Sebastian Fiedler, Viola Denninger, Raphaël PB Jacquat, Lidia Madrigal, Alison Ilsley, Vasilis Kosmoliaptsis, Heike Fiegler, Didier Trono, Tuomas PJ Knowles, Adriano Aguzzi

Using microfluidic affinity profiling, we show how the antibody affinity varies significantly between different individuals after COVID-19 infection while the antibodies neutralise the virus.


 

Microbiota regulates the turnover kinetics of gut macrophages in health and inflammation
Qi Chen, Sajith Nair, Christiane Ruedl

Maintenance of the gut lamina propria–resident macrophage cell pool requires monocyte input during adulthood. Here, Ruedl and colleagues demonstrate that the intestinal microbiome positively influences the replenishment of tissue-resident macrophages under both steady-state and inflammatory conditions.


 

Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infection
AKM Nur-ur Rahman, Jun Liu, Shariq Mujib, Segen Kidane, Arman Ali, Steven Szep, Carrie Han, Phil Bonner, Michael Parsons, Erika Benko, Colin Kovacs, Feng Yun Yue, Mario Ostrowski

Cytotoxic killer CD8+ T cells (CTLs) are central effectors that eliminate virus infected cells. In HIV infection, HIV-specific CTLs become functionally impaired. Herein we investigated the link between metabolism and CD8+ T-cell functional impairment, known as exhaustion.


 

Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells
Jennifer L Vella, Aleksey Molodtsov, Christina V Angeles, Bruce R Branchini, Mary Jo Turk, Yina H Huang

Tissue-resident memory (TRM) T cells in mouse and human melanoma-associated vitiligo skin form large lymphoid aggregates with CXCL16-expressing dendritic cells. CD11c depletion or disruption of the CXCR6-CXCL16 axis results in loss of skin TRM cells and tumor immunity.

 

iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts
Nicholas J Hess, Nikhila S Bharadwaj, Elizabeth A Bobeck, Courtney E McDougal, Shidong Ma, John-Demian Sauer, Amy W Hudson, Jenny E Gumperz

Immunotherapeutic iNKT cells interact with monocytes and T cells in human umbilical cord blood grafts to simultaneously limit inflammation while promoting hematopoietic activity.

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In this Issue

Volume 6, No. 5
May 2023
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