LSA Academic Editor Collection
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We are pleased to present this curated collection of recent articles selected by our Academic Editors. The Scientific Editors at Life Science Alliance (LSA) make decisions on manuscripts in collaboration with five Academic Editors. LSA’s Academic Editors—Julia Cooper, Florent Ginhoux, Sebastian Jessberger, Michael Overholtzer, and Judith Zaugg—are active scientists and cover the main research areas published by the journal. Learn more about our Academic Editors at https://www.life-science-alliance.org/editors. We hope you enjoy reading this collection, and we invite you to follow LSA on Twitter (@LSAjournal). Learn more about submitting your research at https://www.life-science-alliance.org.
Recursive splicing is an unusual form of stepwise mRNA processing involving exons with functional splice donors at their 5′ ends. We use molecular and genetic assays to show three parameters that influence mRNA isoform outcomes during recursive splicing in Drosophila.
Cell division completes when the two daughter cells move their oldest centrosome towards the cytokinetic bridge, which is then cleaved during abscission. The GTPase, Rab11, and the centrosome protein, Pericentrin, work together to coordinate this movement.
Mre11 exonuclease facilitates the processing of stalled replication forks upon mitotic entry, leading to irreversible mitotic progression and mitotic replisome disassembly.
The NEDD4 family E3 ligase Pub1 is regulated by the nutrient environment, TORC2, and Gsk3 signalling pathway to control the level of amino acid transporters on the plasma membrane and thus nutrient uptake.
Chromosome identity regulates the timing of nuclear membrane rupture in micronuclei, in part through an unexpected link between high gene density and improved nuclear lamina organization.
SPTLC2 localizes to the ER and mitochondria where it interacts with ER-localized SPTLC1 to form the sphingolipid-synthesizing enzyme serine palmitoyltransferase at the ER and ER–mitochondria contact sites.
Evolutionary origin of pathogenic variants in human BRCA1 and BRCA2.
Pro-inflammatory TNF is a highly gene-selective inhibitor of the gene expression program of tissue repair and wound healing macrophages.
This study describes Seek & Blastn analysis of targeted and journal corpora with manual results verification to identify human gene research articles with wrongly identified nucleotide sequence reagents.
A TPP1 mutation known to cause telomere shortening and bone marrow failure in humans recapitulates telomere loss but results in severe germline defects in mice without impacting murine hematopoiesis.
Long-term epigenetic gene silencing can be induced independently of DNA methylation by dCas9-KRABd-MeCP2 fusion proteins.
This study investigates phosphorylation of and kindlin recruitment by the double-threonine motif in the β1 integrin cytoplasmic tails.
Using cryo-ET, cell biology, and proteomics, this study shows that aggregating proteins impair the autophagy-lysosomal pathway in neurons by sequestering a subunit of the AP-3 adaptor complex.
Tissue-resident memory (TRM) T cells in mouse and human melanoma-associated vitiligo skin form large lymphoid aggregates with CXCL16-expressing dendritic cells. CD11c depletion or disruption of the CXCR6-CXCL16 axis results in loss of skin TRM cells and tumor immunity.
This study revealed that gut-derived n-butyrate protects against endometriosis by activating the expression of RAP1GAP GTPase to inhibit the RAP1 oncogenic pathway, indicating n-butyrate is linked with intestinal microbiota and endometriosis disease.
Maintenance of the gut lamina propria–resident macrophage cell pool requires monocyte input during adulthood. Here, Ruedl and colleagues demonstrate that the intestinal microbiome positively influences the replenishment of tissue-resident macrophages under both steady-state and inflammatory conditions.