Newest Articles
- Axon terminals control endolysosome diffusion to support synaptic remodelling
Endolysosomes present in the presynaptic terminal move by diffusion constrained by F-actin and increase their mobility during the remodelling of synaptic connectivity to support a local degradative activity.
- UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma
A single, neonatal UVB exposure drives greater UV-signature production in Braf- than Nras-mutant murine melanomas.
- Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations
Cryo-EM structures and molecular simulations of a pentameric ligand-gated ion channel, GLIC, in resting and activating conditions implicate protonation sites and altered dynamics in sequential gating.
- CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP
CNKSR1 functions as a scaffold protein for activation of an EGFR phosphatase, PTPRH, at the plasma membrane through the exclusive interaction with RhoB-GTP which is constitutively degraded by the CUL3/KCTD10 E3 complex.
- Negative correlation of single-cell PAX3:FOXO1 expression with tumorigenicity in rhabdomyosarcoma
Single-cell PAX3:FOXO1 expression in rhabdomyosarcoma is variable. PAX3:FOXO1 low cell states are characterized by more efficient adhesion, migration and tumor-propagating capacity.
- Stepwise transmigration of T- and B cells through a perivascular channel in high endothelial venules
Intravital imaging reveals stepwise transmigration cascade of T- and B cells across endothelial cells and fibroblastic reticular cells in lymph node high endothelial venules via hot spots.
- Deletion of a pseudogene within a fragile site triggers the oncogenic expression of the mitotic CCSER1 gene
Frequent deletions impacting the FRA4F fragile site leads to the oncogenic overexpression of the corresponding CCSER1 gene, through the deletion of the TMSB4XP8 pseudogene. The ensuing CCSER1 overexpression elicits mitotic instability, targetable with aurora kinase inhibitors.
- Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancy
The current study presents first CP murine model that show IL-18–induced eosinophil inflammation-mediated induction of oncogenic proteins and several pathological malignant characteristics.
- Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup
The present study unveils the molecular mechanism through which neurons in vitro compensate age-associated proteostasis defects by increasing exosome release.
- TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration
This study identifies the endolysosomal two-pore channel TPC2 as a potential novel drug target for age-related macular degeneration (AMD). Inhibition of TPC2 reduces two key clinical hallmarks of the AMD, retinal inflammation and formation of leaky choroi.