Newest Articles
- Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinoma
Single-cell RNA-Seq unravels heterogeneity and compartmentalization of both hepatitis B virus and cancer identifying new candidate pathways for viral hepatocarcinogenesis.
- Functional annotation of noncoding mutations in cancer
Recurrent regulatory mutations affecting transcription factor binding sites in 2,500 cancer samples.
- Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer
This work identifies the use of exosomes to specifically deliver CRISPR/Cas9 to target oncogenic KrasG12D mutation in pancreatic cancer as a nonviral therapeutic strategy.
- Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity
hnRNP E1 binds polycytosine tracts of DNA and monitors genome integrity.
- Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila
CRISPR knockout of msl-2 and epigenome analyses in Anopheles reveal that X chromosome dosage compensation in mosquitos and Drosophila is achieved by two different molecular mechanisms.
- Long noncoding RNA HOTAIR interacts with Y-Box Protein-1 (YBX1) to regulate cell proliferation
The authors determined that HOTAIR specifically bind to YBX1 and promote its nuclear translocation, and then regulating cell proliferation by stimulating the PI3K/Akt and ERK/RSK signaling pathways.
- Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling
A signaling cascade composing M3, EphB/ephrin-B, and MEK synergizes to guide the homeostasis of intestinal epithelial cell growth and differentiation following modifications of the cholinergic intestinal niche.
- A serum proteome signature to predict mortality in severe COVID-19 patients
A serum proteome panel, which includes several type-3 cystatins and inter-α-trypsin inhibitors, predicts mortality in severe COVID-19 patients very well, in three independent cohorts.
- The stabilized Pol31–Pol3 interface counteracts Pol32 ablation with differential effects on repair
DNA pol δ is needed for lagging strand replication and DNA repair. We shed light on both distinct and common roles of the second and third subunits, Pol31 and Pol32, in S-phase linked repair pathways.
- PNKP is required for maintaining the integrity of progenitor cell populations in adult mice
Knockout of Pnkp in adult mice impairs the growth of hair follicle, spermatogonial, and neural progenitor populations.