Newest Articles
- AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation
This work reveals a novel function of WWP1 E3 ligase in the mono-ubiquitination of AMOTL2, which enables the binding and activation of LATS kinases upon contact inhibition.
- Dystrophin involvement in peripheral circadian SRF signalling
Absence of integral sarcolemmal protein, dystrophin, disrupts the RhoA-actin-SRF cascade in skeletal muscle, with subsequent dysregulation of downstream-SRF circadian targets and circadian rhythm.
- Tyrosine phosphorylation of lamin A by Src promotes disassembly of nuclear lamina in interphase
Phosphorylation of lamin A at tyrosine residue 45 by Src has an adverse effect on the assembly of nuclear lamina, which may be involved in nuclear dysmorphia, genomic instability, and nuclear plasticity in interphase.
- Extracellular matrix mediates moruloid-blastuloid morphodynamics in malignant ovarian spheroids
Expression dynamics of basement membrane-like extracellular matrix and fibronectin regulate transitions between solid (moruloid) and cavitational (blastuloid) phenotypes of ovarian cancer spheroids.
- Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids
Here, the authors evaluate prime editing in human adult stem cell–derived organoids. TP53 mutations are modeled in hepatocyte and colon organoids and the clinical application of prime editing is evaluated by repairing mutations in CFTR without genome-wide off-targets.
- Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells
Tissue-resident memory (TRM) T cells in mouse and human melanoma-associated vitiligo skin form large lymphoid aggregates with CXCL16-expressing dendritic cells. CD11c depletion or disruption of the CXCR6-CXCL16 axis results in loss of skin TRM cells and tumor immunity.
- Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19
Integrated human/SARS-CoV-2 metabolic models present novel treatment strategies against COVID-19 and provide insights into viral entry inhibition, immune regulation, and drug optimisation strategies.
- Incomplete antiviral treatment may induce longer durations of viral shedding during SARS-CoV-2 infection
Treatments initiated early, such as 0.5 d after virus inoculation, with intermediate to relatively high efficacy (30–70% inhibition of virus replication) yield a prolonged duration of viral shedding (by about 6.0 d) compared with no treatment.
- Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells
Using genetically encoded Förster resonance energy transfer calcium sensors for the peroxisome, this study dissects the previously contentious peroxisome involvement in calcium handling in HeLa cells and in cardiomyocytes derived from human induced pluripotent stem cells.
- High-dose intravenous immunoglobulins might modulate inflammation in COVID-19 patients
High-dose of IVIG show immunomodulatory properties that may be useful for controlling the hyperinflammatory status observed in COVID-19 patients.