Newest Articles
- Accessory genes define species-specific routes to antibiotic resistance
In this study, we show how decision tree models can accurately predict the AMR phenotype, and this study highlights that resistance is a result of multi-gene interactions, which are often species-specific.
- Enhancer mutations modulate the severity of chemotherapy-induced myelosuppression
Using transcriptome and interactome maps with patients’ WGS, this research uncovers the role of noncoding mutations in the myelosuppression predisposition, advancing personalized cancer treatment.
- The origin, evolution, and molecular diversity of the chemokine system
Extensive phylogenetic analysis of chemokine signalling molecules reveals the origin and evolution of canonical and non-canonical components, shedding light on the evolution of this complex system.
- E. hellem Ser/Thr protein phosphatase PP1 targets the DC MAPK pathway and impairs immune functions
Intracellular pathogen E. hellem suppressed host DCs’ immune functions via pathogen-derived serine/threonine protein phosphatase PP1 directly targeting the host p38α/MAPK pathway.
- Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses
The E3 ubiquitin ligase RNF12/RLIM is mutated in intellectual disability and controls developmental gene expression. We show that chromatin targeting of RNF12 is required for substrate ubiquitylation and transcriptional responses, providing insight into mechanisms by which ubiquitylation regulates gene expression.
- CLN3 deficiency leads to neurological and metabolic perturbations during early development
Cln3 CRISPR mutant zebrafish larvae display BMP depletion and accumulation of glycerophosphodiesters and cholesteryl esters at very early developmental stages, recapitulating key features of human CLN3 disease.
- Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography
Cryo-electron tomography and subtomogram averaging reveal new structural features at the base of the light-sensing cilia of retinal rods, including the basal body, the Y-links between axoneme and membrane, and the ciliary necklace of the transition zone.
- USP27X variants underlying X-linked intellectual disability disrupt protein function via distinct mechanisms
This study uncovers mechanisms by which X-linked intellectual disability disorder 105 (#300984; OMIM) variants alter USP27X biology and function.
- Early Atf4 activity drives airway club and goblet cell differentiation
PERK/Atf4 drives airway epithelial differentiation, impacting secretory cell numbers, revealing ATF4’s role in respiratory tract regeneration.
- Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors
Two anti-PD-1 antibodies bind to distinct glycoforms of PD-1 found on cells or in blood, highlighting the potential of target glycoprofiling in the development of differentiated therapeutics.