Newest Articles
- Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration
By knocking out all four EGFR ligands expressed in MDCK cells, this study shows the redundant and specific roles of each EGFR ligand in the ERK activation waves during collective cell migration.
- HERVH-derived lncRNAs negatively regulate chromatin targeting and remodeling mediated by CHD7
Mutations in CHD7 are diagnostic for human CHARGE syndrome. RNAs expressed from the HERVH repeats modulate CHD7 function providing one mechanism for regulation of differentiation of pluripotent cells.
- SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart
In a unique model of fluorescent based mapping of EV recipient cells, RBC-EVs were found to signal to cardiac cells and regulate gene expression in a model of ischemic heart failure.
- A brain-specific pgc1α fusion transcript affects gene expression and behavioural outcomes in mice
This study shows that loss of a brain-specific fusion isoform of PGC1a leads to up-regulation of genes and motor impairments in mice, suggesting functional differences between PGC1 isoforms in the brain.
- Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline
A TPP1 mutation known to cause telomere shortening and bone marrow failure in humans recapitulates telomere loss but results in severe germline defects in mice without impacting murine hematopoiesis.
- Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival
BTK is a dominant bioactive kinase expressed within both cancer and immune cells of GBM tissue. Complex cell co-cultures might better model the impact of kinase inhibitors as therapeutics in GBM.
- Interplay between MPIase, YidC, and PMF during Sec-independent insertion of membrane proteins
Charges in the N-terminal region and the synthesis level of membrane proteins with N-out topology determine YidC and PMF dependencies with the interplay between glycolipid MPIase, YidC, and PMF.
- Non-canonical activation of the ER stress sensor ATF6 by Legionella pneumophila effectors
Legionella pneumophila secretes toxins into the host cell that induce the non-canonical processing and activation of the ER stress sensor and transcription factor ATF6 via a mechanism that is distinct from the canonical pathway activated by unfolded protein buildup.
- Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeres
The yeast chromatin protein Set4 regulates expression of stress response genes within subtelomeric regions under normal and stress conditions and modulates histone deacetylase activity at chromatin.
- Suppression of isoprenylcysteine carboxylmethyltransferase compromises DNA damage repair
Inhibition of isoprenylcysteine carboxylmethyltransferase reduces cancer cells’ ability to repair DNA damage by suppressing the expression of critical DNA damage repair pathway genes, hence increasing their vulnerability to DNA damaging insults such as PARP inhibitors and other DNA damage agents.