Newest Articles
- CLN3 deficiency leads to neurological and metabolic perturbations during early development
Cln3 CRISPR mutant zebrafish larvae display BMP depletion and accumulation of glycerophosphodiesters and cholesteryl esters at very early developmental stages, recapitulating key features of human CLN3 disease.
- Centriole and transition zone structures in photoreceptor cilia revealed by cryo-electron tomography
Cryo-electron tomography and subtomogram averaging reveal new structural features at the base of the light-sensing cilia of retinal rods, including the basal body, the Y-links between axoneme and membrane, and the ciliary necklace of the transition zone.
- USP27X variants underlying X-linked intellectual disability disrupt protein function via distinct mechanisms
This study uncovers mechanisms by which X-linked intellectual disability disorder 105 (#300984; OMIM) variants alter USP27X biology and function.
- Early Atf4 activity drives airway club and goblet cell differentiation
PERK/Atf4 drives airway epithelial differentiation, impacting secretory cell numbers, revealing ATF4’s role in respiratory tract regeneration.
- Variable PD-1 glycosylation modulates the activity of immune checkpoint inhibitors
Two anti-PD-1 antibodies bind to distinct glycoforms of PD-1 found on cells or in blood, highlighting the potential of target glycoprofiling in the development of differentiated therapeutics.
- Pridopidine subtly ameliorates motor skills in a mouse model for vanishing white matter
Assessment of the therapeutic efficacy of 4-PBA, TUDCA, and pridopidine in a vanishing white matter mouse model shows that only pridopidine subtly ameliorates motor skills.
- Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport
The membrane-bound serine protease Tmprss2 is required for ENaC-mediated transepithelial sodium and EpCAM-mediated paracellular transport in kidney cells.
- 2′,3′ cyclic nucleotide 3′ phosphodiesterase 1 functional isoform antagonizes HIV-1 particle assembly
CNP1, not CNP2, is the primary isoform inhibiting HIV-1, highlighting posttranslational regulation in CNP antiviral role.
- Gene architecture is a determinant of the transcriptional response to bulky DNA damages
A comparative genomic study of the transcriptomic response to bulky DNA damages uncovers novel response genes and the features of their structure that allow them to be better repaired and transcribed.
- Sterile protection against P. vivax malaria by repeated blood stage infection in the Aotus monkey model
Repeated blood stage infections with the human malaria parasite, Plasmodium vivax, induce sterile strain-specific and partial strain-transcendent protection in the Aotus monkey model.