Newest Articles
- Replication-associated inversions are the dominant form of bacterial chromosome structural variation
Prokaryotic rearrangements symmetric to the replication origin are identified across 247 bacterial species. Large-scale inversions are found to be highly prevalent across species, and their mediating factors are examined. The full pipeline and dataset are available on GitHub at https://github.com/mdiorio371/RASR.
- The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import
Yeast cells employ the cytosolic ubiquitin system to increase the capacity of the mitochondrial import machinery during phases of metabolic transitions.
- Low expression of EXOSC2 protects against clinical COVID-19 and impedes SARS-CoV-2 replication
Genetic evidence and in vitro experiments with live virus suggest EXOSC2 depletion can reduce SARS-CoV-2 replication without significant toxicity.
- Direct CD32 T-cell cytotoxicity: implications for breast cancer prognosis and treatment
CD32-chimeric receptor T cell identifies CD32 cell surface ligand(s), on breast cancer (BC) cells, leading to BC cell elimination in vitro and in vivo and allowing detection of genes prognostically relevant.
- A dominant negative mitofusin causes mitochondrial perinuclear clusters because of aberrant tethering
Our analysis of a CMT2A-associated mitofusin variant reveals that aberrant mitochondrial tethering results in perinuclear clusters and that conformational dynamics in Hinge 2 are required to progress from membrane tethering to membrane fusion.
- Whole-exome sequencing of epithelial ovarian carcinomas differing in resistance to platinum therapy
Exploration of the prognostic and predictive significance of exome variation in epithelial ovarian carcinoma patients, with TP53, Hippo, homologous recombination genes, and the SBS6 signature as the most interesting results.
- Autoimmune RNA dysregulation and seizures: therapeutic prospects in neuropsychiatric lupus
Lupus autoantibodies directed at neuroregulatory BC200 RNA cause seizure susceptibility in mice, but sequestration with antigen prevents seizures, indicating utility in therapeutic interventions.
- High-resolution structure of a fish aquaporin reveals a novel extracellular fold
The structural and functional characterization of a fish AQP reveals a water-specific AQP with unique structural features that may have implications for channel gating in response to osmotic changes.
- Aerocyte specification and lung adaptation to breathing is dependent on alternative splicing changes
Perinatal cell type–specific alternative splicing changes modulate the intercellular communication between alveolar epithelial AT1 and endothelial cells, leading to the specification of aerocytes, a specialized type of alveolar capillary ECs critical for gas exchanges.
- Exploratory meta-analysis of hypoxic transcriptomes using a precise transcript reference sequence set
Exploratory meta-analysis of hypoxic RNA-seq data using FANTOM-CAT as a reference transcriptome facilitates the evaluation of relationship between sense–antisense transcripts from the same locus.