Newest Articles
- Lack of peroxisomal catalase affects heat shock response in Caenorhabditis elegans
The authors present a previously unknown crosstalk between peroxisomes and the heat shock response, whereby the peroxisomal catalase is vital for cellular capacity to survive heat stress and undergo heat-induced lifespan extension.
- C-to-U RNA deamination is the driving force accelerating SARS-CoV-2 evolution
The authors propose that the host-mediated C-to-U RNA editing event, which is also affected by the RNA structure, is the driving force that accelerates SARS-CoV-2 mutation and evolution.
- The potential of a universal influenza virus-like particle vaccine expressing a chimeric cytokine
Herein, a virus-like particle vaccine with chimeric cytokine shows the protective efficacy against different strains of influenza virus, laying the foundation for designing a universal influenza vaccine.
- Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing
Targeted capture sequencing (CapIG-seq) is a novel, efficient, and effective approach to examine multiple genomic alterations in ctDNA and bone marrow aspirates of patients with multiple myeloma.
- Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis
NQO1 catalyzes the reduction of tanshinones to detoxify lipid peroxyl radicals and inhibit ferroptosis both in vitro and in vivo, providing a molecular mechanism for the therapeutic effects of tanshinones, such as cardiac protection.
- In vivo probing of SECIS-dependent selenocysteine translation in Archaea
By turning a bacterial reporter into an archaeal selenoprotein, in vivo probing of structure–function relations during UGA recoding for selenoprotein synthesis in Archaea is greatly facilitated.
- CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau
Using a genome-wide CRISPRi screen, we identified ANKLE2, BANF1, NUSAP1, EIF1AD, and VPS18 as novel regulators of tau pathology induced by both exosome-like extracellular vesicles and free tau seeds.
- Miro GTPase domains regulate the assembly of the mitochondrial motor–adaptor complex
Relocalizing the mitochondrial motor–adaptor protein Miro to peroxisomes and systematically manipulating each GTPase domain reveal the importance of the N-terminal GTPase domain of Miro1 for regulating mitochondrial transport.
- Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers
The disruption of circadian rhythms because of lipid overload may lead to epigenomic changes that influence metabolism. Thus, a dietary or therapeutic modulation of lipid levels, a cornerstone in the treatment of metabolic disorders, may prevent circadian misalignment in peripheral tissues.
- circEXOC5 promotes acute lung injury through the PTBP1/Skp2/Runx2 axis to activate autophagy
circEXOC5 activates autophagy and promotes acute lung injury via stimulating the Skp2 decay to stabilize Runx2 by interacting with PTBP1.