Newest Articles
- SHIP1 deficiency causes inflammation-dependent retardation in skeletal growth
SHIP1 plays a cell-intrinsic role in osteoclast function and development, yet skeletal growth retardation in SHIP1-deficient mice is dependent on lymphocyte-induced inflammation.
- Ageing-dependent thiol oxidation reveals early oxidation of proteins with core proteostasis functions
Proteome-wide analysis of thiol oxidation during chronological ageing of yeast reveals evolutionarily conserved proteins as early-oxidation targets with a potential impact on proteostasis regulation.
- Breast implant surface topography triggers a chronic-like inflammatory response
This study explores the impact of breast implant surface topographies on immune responses, using analyses of periprosthetic fluids and in vitro cultures on model surface replicas, revealing that macrotextured implants significantly induce chronic-like inflammatory reactions.
- IFT88 maintains sensory function by localising signalling proteins along Drosophila cilia
DmIFT88 is dispensable to preserve the auditory ciliary structure but is critical to maintain sensory cilia function through binding and localisation of the ciliary proteins Iav and DmGucy2d.
- The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation
This study identifies the RNA-binding protein Musashi2 as a novel regulator of myogenesis. Msi2 regulates myoblast differentiation via controlling autophagic protein LC3 expression. Loss of Msi2 results in defective skeletal muscle function in vivo.
- Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva
Oxidative phosphorylation plays a pivotal role in heterotopic ossification associated with fibrodysplasia ossificans progressiva, underscoring its potential as a significant therapeutic target.
- Variety in the USP deubiquitinase catalytic mechanism
Quantitative analysis shows that USP family members have varying catalytic triads. Their third and fourth catalytic residues change in role and importance for nucleophilic attack and catalysis.
- Correction: Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish
The vast majority (99%) of mitochondrial proteins are encoded by the nuclear genome, synthesized in the cytosol and imported into the organelle. Here we study the principles of mitochondrial import in vivo from the RNA perspective using zebrafish.
- Oral bacteria induce IgA autoantibodies against a mesangial protein in IgA nephropathy model mice
This work shows that the CBX3, atypically expressed on the mesangial cell, is a target of IgA auto-Abs in IgA nephropathy model mice and patients. Such IgA auto-Abs are induced by oral bacteria in mice.