Newest Articles
- LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug
We show the ability of LACTB to function as a tumor suppressor in ovarian cancer through down-regulation of Slug and induction of differentiation.
- Loss of autism-candidate CHD8 perturbs neural crest development and intestinal homeostatic balance
A combination of zebrafish and transcriptomic analyses revealed the role of the autism-candidate chd8 in the development of the enteric nervous system, serotonin metabolism, and intestinal integrity.
- SMA-linked SMN mutants prevent phase separation properties and SMN interactions with FMRP family members
The survival motor neuron (SMN) protein associates with translation regulators and phase-separates into RNA-stabilized droplets that are likely candidates for the formation of nuclear and cytoplasmic membraneless organelles.
- Lipid saturation induces degradation of squalene epoxidase for sterol homeostasis and cell survival
The authors describe the ER-associated degradation of Erg1 under increased membrane lipid saturation and show its importance in balancing sterol levels for membrane integrity in budding yeast.
- Protein and RNA ADP-ribosylation detection is influenced by sample preparation and reagents used
Mono(ADP-ribosyl)ation is an emerging modification, for which recently detection reagents were generated. We cross-validated all reagents and observe remarkable differences in efficiency, depending on the substrate investigated and on the methods that are used.
- Lack of peroxisomal catalase affects heat shock response in Caenorhabditis elegans
The authors present a previously unknown crosstalk between peroxisomes and the heat shock response, whereby the peroxisomal catalase is vital for cellular capacity to survive heat stress and undergo heat-induced lifespan extension.
- C-to-U RNA deamination is the driving force accelerating SARS-CoV-2 evolution
The authors propose that the host-mediated C-to-U RNA editing event, which is also affected by the RNA structure, is the driving force that accelerates SARS-CoV-2 mutation and evolution.
- The potential of a universal influenza virus-like particle vaccine expressing a chimeric cytokine
Herein, a virus-like particle vaccine with chimeric cytokine shows the protective efficacy against different strains of influenza virus, laying the foundation for designing a universal influenza vaccine.
- Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing
Targeted capture sequencing (CapIG-seq) is a novel, efficient, and effective approach to examine multiple genomic alterations in ctDNA and bone marrow aspirates of patients with multiple myeloma.
- Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis
NQO1 catalyzes the reduction of tanshinones to detoxify lipid peroxyl radicals and inhibit ferroptosis both in vitro and in vivo, providing a molecular mechanism for the therapeutic effects of tanshinones, such as cardiac protection.