Newest Articles
- An isoform-specific function of Cdc42 in regulating mammalian Exo70 during axon formation
The brain-specific isoform of the GTPase Cdc42 is shown to promote axon formation by interacting with the exocyst tethering complex and increasing exocytosis downstream of its activator Arhgef7.
- Integrin ligands block mechanical signal transduction in baroreceptors
The binding of integrins to specific sequences in extracellular matrix forms the mechanical coupling to transfer stretch applied on the vascular wall to the baroreceptors.
- Integrin β1/FAK/SRC signal pathway is involved in autism spectrum disorder in Tspan7 knockout rats
TSPAN7 knockout causes ASD-like phenotypes in rats through the integrin β1/FAK/SRC signal pathway, which provides novel insights into the role of TSPAN7 in psychiatric diseases, highlighting SRC as a potential target.
- Tyrosine phosphorylation controlled poly(A) polymerase I activity regulates general stress response in bacteria
We show a tyrosine phosphorylation–controlled poly(A) polymerase I polyadenylation activity regulated stress response mechanism in bacteria that is distinct and operates downstream of the primary stress regulator RpoS.
- Concordance of MERFISH spatial transcriptomics with bulk and single-cell RNA sequencing
Single-cell RNA-seq is an important technology for capturing gene expression in individual cells. It has limitations as spatial context and accurate representation of cell types in the tissue are lost. Here, we show that MERFISH is comparable to scRNA-seq.
- Convergent evolution and horizontal gene transfer in Arctic Ocean microalgae
The Arctic Ocean stands apart from other oceans. Using multiple genomes and transcriptomes from cultured and environmental sources, we found distinct genetic modifications in Arctic microalgae consistent with biogeographically constrained trait selectivity as an adaptive force in algal evolution.
- Ectopic CH60 mediates HAPLN1-induced cell survival signaling in multiple myeloma
This study defines ectopic mitochondrial chaperonin 60 (CH60) on the multiple myeloma cell surface as a HAPLN1 matrikine receptor that signals via TLR4 to induce NF-κB signaling and drug resistance.
- Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19
Severe COVID-19 is associated with alterations to the neutrophil compartment with circulating hyperactive immature neutrophils and a maintenance of CXCR2 expression.
- Correction: Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome
Single cell sequencing of γδ-T cells from human blood and tumours revealed novel markers of subtypes with distinct effector functions and a subtype that is associated with favourable clinical outcome.
- Identifying novel regulators of placental development using time-series transcriptome data
Network analysis of RNA-seq data generated from mouse placenta at embryonic days 7.5, 8.5, and 9.5 identifies novel regulators of placental development.