Newest Articles
- Mitochondria isolated from lipid droplets of white adipose tissue reveal functional differences based on lipid droplet size
In the current study, we show an optimized protocol using proteolytic treatment that enables the isolation of peridroplet mitochondria (PDM) from white adipose tissue (WAT), revealing a unique function of WAT PDM that depends on the heterogeneity of lipid droplet size.
- IMPA1 dependent regulation of phosphatidylinositol 4,5-bisphosphate and calcium signalling by lithium
This study demonstrates that lithium that is used to treat bipolar disorder acts via IMPA1 to regulate calcium signalling and neuronal excitability.
- Structural maintenance of chromosomes (SMC) proteins are required for DNA elimination in Paramecium
This work focuses on two functionally distinct paralogues of SMC4 in Paramecium. SMC4-1 appears to have a classical function as a condensin subunit whereas SMC4-2 is required for developmental DNA elimination process.
- Correction: LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug
We show the ability of LACTB to function as a tumor suppressor in ovarian cancer through down-regulation of Slug and induction of differentiation.
- Proteomic-based stratification of intermediate-risk prostate cancer patients
This study demonstrates the ability of a protein-based signature to risk-stratify prostate cancer patients with Gleason grade groups 2 and 3 and predict the risk of biochemical recurrence.
- Correction: The coenzyme A precursor pantethine enhances antitumor immunity in sarcoma
VitB5 level becomes limiting in sarcomas. It is regulated by the pantetheinase activity of VNN1. VNN1 expression in sarcomas is associated with better prognosis and immune infiltration. In mice, complementation with pantethine, a vitB5 precursor, boosts antitumor immunity.
- Common analysis of direct RNA sequencinG CUrrently leads to misidentification of m5C at GCU motifs
Published predictions of 5-methylcytosine at GCU sites inferred from direct RNA sequencing and the Tombo Alternative Model should be reconsidered unless further validated with orthogonal methods.
- Analysis of the indispensable RAD51 cofactor BRCA2 in Naganishia liquefaciens, a Basidiomycota yeast
Identification of the BRCA2 homolog in the Basidiomycota yeast Naganishia liquefaciens reveals the general attributes of fungal BRCA2 and its essential role in Rad51-mediated homologous recombination.
- A dual-targeted drug inhibits cardiac ryanodine receptor Ca2+ leak but activates SERCA2a Ca2+ uptake
Our study identified a first multi-targeted compound (GM1869) inhibiting RyR2-mediated Ca2+ leak together with activating SERCA2a function that may represent a critical breakthrough for treatment of diastolic Ca2+ leak in heart failure.
- Endothelial cells adopt a pro-reparative immune responsive signature during cardiac injury
scRNA-seq uncovers an endothelial cell (EC) subpopulation with immune responsive signatures in cardiac injury. Profiling of human heart failure samples reveals EC-specific immune responsive signatures in adult and pediatric heart failure. ECs can adopt immune responsive signatures during cardiac stress.