Newest Articles
- Changes in searching behaviour of CSL transcription complexes in Notch active conditions
Single molecule live imaging of the Notch pathway transcription factor CSL reveals how its properties change in Notch active nuclei, acquiring exploratory behaviour.
- The structural basis for deubiquitination by the fingerless USP-type effector TssM
The structural characterization of the bacterial effector deubiquitinase TssM from Burkholderia pseudomallei, belonging to the USP family, reveals that TssM lacks the canonical “Fingers” subdomain of USP-type deubiquitinases and evolved instead the functionally analog “Littlefinger” loop for ubiquitin binding.
- The AP-2 complex interacts with γ-TuRC and regulates the proliferative capacity of neural progenitors
This study reveals a novel role of endocytic adaptor AP-2 in orchestrating centrosome function and cell cycle progression through its interaction with components of the γ-TuRC complex, providing valuable insights for addressing neurodevelopmental and neurodegenerative disorders linked to AP-2 dysfunction.
- Human RAD52 stimulates the RAD51-mediated homology search
This study sheds new molecular light on the role of RAD52 in homologous recombination using direct electron microscopy visualization of its interdependent activity with RAD51 and BRCA2 onto resected double strand break extremity.
- tRF-1:30-Gly-CCC-3 inhibits thyroid cancer via binding to PC and modulating metabolic reprogramming
This study reports a mechanism of tRNA fragments in PTC whereby tRF-30 controls PC abundance and subsequent TCA cycle anaplerosis to affect metabolic reprogramming and cancer progression.
- RedRibbon: A new rank–rank hypergeometric overlap for gene and transcript expression signatures
RedRibbon is a comparative analysis tool of differential omics analyses to reveal overlapping features between two differential studies, with high performance, accuracy, and simplicity in use.
- A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells
This work describes a high-throughput cellular assay specifically designed to study the understudied inhibitory signalling pathway in T cells.
- Mitochondria isolated from lipid droplets of white adipose tissue reveal functional differences based on lipid droplet size
In the current study, we show an optimized protocol using proteolytic treatment that enables the isolation of peridroplet mitochondria (PDM) from white adipose tissue (WAT), revealing a unique function of WAT PDM that depends on the heterogeneity of lipid droplet size.
- IMPA1 dependent regulation of phosphatidylinositol 4,5-bisphosphate and calcium signalling by lithium
This study demonstrates that lithium that is used to treat bipolar disorder acts via IMPA1 to regulate calcium signalling and neuronal excitability.
- Structural maintenance of chromosomes (SMC) proteins are required for DNA elimination in Paramecium
This work focuses on two functionally distinct paralogues of SMC4 in Paramecium. SMC4-1 appears to have a classical function as a condensin subunit whereas SMC4-2 is required for developmental DNA elimination process.