Newest Articles
Laminin is the ECM niche for trophoblast stem cellsLaminin functions as an ECM niche factor for trophoblast stem cells and secures trophoblast stem cell expansion through its interactions with integrin.
TRAP1 chaperone protein mutations and autoinflammationThis study identifies patients with autoinflammation and mutations affecting the mitochondrial/ER protein chaperone TRAP1, either alone or digenic, with MEFV mutation possibly synergizing to produce severe disease. TRAP1 mutations lead to increased mitochondrial reactive oxygen species and may contribute to autoinflammation.
Oscillatory cAMP signaling rapidly alters H3K4 methylationThis work explores how GPCR-cAMP signaling dynamically influences histone methylation by altering intracellular labile Fe(II) levels and subsequently modulating histone demethylase activity.
CLIC4 and CLIC1 bridge plasma membrane and cortical actin network for a successful cytokinesisCLIC members are required for the progression of cytokinesis by coupling the plasma membrane and cortical actin network at the cleavage furrow and polar cortex.
Loss of autophagy impairs physiological steatosis by accumulation of NCoR1Autophagy regulates fatty acid and triglyceride synthesis at the transcriptional level by fine-tuning the levels of NCoR1, a negative regulator of nuclear receptors. Defective autophagy impairs physiological steatosis both under fasting conditions and after hepatectomy.
In vivo and in vitro knockout system labelled using fluorescent protein via microhomology-mediated end joiningThis study provides a new method that enables the labelling of knockout cells with fluorescent protein through microhomology-mediated end joining (MMEJ)–based knock-in.
A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virusAn expanded hydrophobic cavity within the structurally constrained receptor-binding site of the Cedar virus attachment glycoprotein facilitates idiosyncratic utilization of ephrin-B1.
Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylationMitochondrial fusion requires a conformational change in α4 of the GTPase domain, followed by AAA-ATPase regulation, thus revealing striking mechanistic similarities between small and large GTPases.
Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defenseIrgb6 has a role in the cell-autonomous response against T. gondii and involves ubiquitination and breakdown of vacuoles via binding of a specific phospholipid on the parasitophorous vacuole membrane.
aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion modelTransient activation of YAP with a modified mRNA after ischemia-reperfusion stress reduces cardiac inflammation, attenuates cardiac hypertrophic remodeling and helps to salvage the myocardium.
