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Newest Articles

  • Incipient sympatric speciation in wild barley caused by geological-edaphic divergence
    Open Access
    Incipient sympatric speciation in wild barley caused by geological-edaphic divergence

    Kexin Li, Xifeng Ren, Xiaoying Song, Xiujuan Li, Yu Zhou, Eli Harlev, Dongfa Sun, Eviatar Nevo

    Kexin Li ... Eviatar Nevo

    Published 20 October 2020

    Sympatric speciation is still contentious but here based on genome-wide analysis; we show incipient sympatric speciation of an emerging new wild barley species from Hordeum spontaneum, the progenitor of all cultivated barleys at “Evolution Plateau” (EP), Upper Galilee, Israel.

  • Role of opioid signaling in kidney damage during the development of salt-induced hypertension
    Open Access
    Role of opioid signaling in kidney damage during the development of salt-induced hypertension

    Daria Golosova, Oleg Palygin, Ruslan Bohovyk, Christine A Klemens, Vladislav Levchenko, Denisha R Spires, Elena Isaeva, Ashraf El-Meanawy, Alexander Staruschenko

    Daria Golosova ... Alexander Staruschenko

    Published 12 October 2020

    Stimulation of kappa opioid receptors modulates calcium influx via TRPC6 channels in podocytes, which ultimately compromises the integrity of the glomerular filtration barrier and promotes a marked worsening of blood pressure control and renal damage.

  • A double role of the Gal80 N terminus in activation of transcription by Gal4p
    Open Access
    A double role of the Gal80 N terminus in activation of transcription by Gal4p

    Annekathrin Reinhardt-Tews, Rościsław Krutyhołowa, Christian Günzel, Constance Roehl, Sebastian Glatt, Karin D Breunig

    Annekathrin Reinhardt-Tews ... Karin D Breunig

    Published 9 October 2020

    Activation of gene expression by Gal4p in K. lactis requires an element in the N terminus of KlGal80p that mediates nuclear co-import of KlGal1p and galactokinase inhibition to support the co-inducer function of KlGal1p.

  • In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer
    Open Access
    In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer

    Linda K Rushworth, Victoria Harle, Peter Repiscak, William Clark, Robin Shaw, Holly Hall, Martin Bushell, Hing Y Leung, Rachana Patel

    Linda K Rushworth ... Rachana Patel

    Published 8 October 2020

    A whole genome in vivo CRISPR/Cas9 screen identifies TCEAL1 as a potential target to sensitise prostate cancer cells to docetaxel to improve the efficacy of chemotherapy.

  • Neurturin regulates the lung-resident macrophage inflammatory response to viral infection
    Open Access
    Neurturin regulates the lung-resident macrophage inflammatory response to viral infection

    Emma Connolly, David J Morgan, Miriam Franklin, Angela Simpson, Rajesh Shah, Oliver J Brand, Christopher P Jagger, Joshua Casulli, Karishma Mohamed, Aleksander M Grabiec, Tracy Hussell

    Emma Connolly ... Tracy Hussell

    Published 5 October 2020

    The neurotrophic factor RET is induced in lung macrophages by viral triggers and activation via its ligand neurturin regulates matrix proteins and cytokines that shape the inflammatory response.

  • Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data
    Open Access
    Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data

    Jovan Tanevski, Thin Nguyen, Buu Truong, Nikos Karaiskos, Mehmet Eren Ahsen, Xinyu Zhang, Chang Shu, Ke Xu, Xiaoyu Liang, Ying Hu, Hoang VV Pham, Li Xiaomei, Thuc D Le, Adi L Tarca, Gaurav Bhatti, Roberto Romero, Nestoras Karathanasis, Phillipe Loher, Yang Chen, Zhengqing Ouyang, Disheng Mao, Yuping Zhang, Maryam Zand, Jianhua Ruan, Christoph Hafemeister, Peng Qiu, Duc Tran, Tin Nguyen, Attila Gabor, Thomas Yu, Justin Guinney, Enrico Glaab, Roland Krause, Peter Banda, DREAM SCTC Consortium, Gustavo Stolovitzky, Nikolaus Rajewsky, Julio Saez-Rodriguez, Pablo Meyer

    Jovan Tanevski ... Pablo Meyer

    Published 24 September 2020

    We describe and provide an array of diverse methods to predict cellular positions in tissue from RNA-seq data selecting mapping genes according to their spatial/statistical properties and their effect on improving the cell positioning.

  • Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast
    Open Access
    Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast

    Jinbo Fan, Hui Jin, Bailey A Koch, Hong-Guo Yu

    Jinbo Fan ... Hong-Guo Yu

    Published 23 September 2020

    The canonical LINC complex is composed of two different transmembrane proteins; this work reveals the heterotrimeric composition of the telomere-associated LINC complex in budding yeast.

  • Fungal mycelia and bacterial thiamine establish a mutualistic growth mechanism
    Open Access
    Fungal mycelia and bacterial thiamine establish a mutualistic growth mechanism

    Gayan Abeysinghe, Momoka Kuchira, Gamon Kudo, Shunsuke Masuo, Akihiro Ninomiya, Kohei Takahashi, Andrew S Utada, Daisuke Hagiwara, Nobuhiko Nomura, Naoki Takaya, Nozomu Obana, Norio Takeshita

    Gayan Abeysinghe ... Norio Takeshita

    Published 22 September 2020

    Bacterial cells travel along fungal highway and pay thiamine as a toll to the fungus. Simultaneous spatial and metabolic interactions in communicating bacterial and fungal species establish a mutualism that facilitates them to obtain an environmental niche and nutrient.

  • Predicting gene regulatory networks from cell atlases
    Open Access
    Predicting gene regulatory networks from cell atlases

    Andreas Fønss Møller, Kedar Nath Natarajan

    Andreas Fønss Møller ... Kedar Nath Natarajan

    Published 21 September 2020

    Integrated single-cell gene regulatory network from three mouse cell atlases captures global and cell type–specific regulatory modules and crosstalk, important for cellular identity.

  • Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer
    Open Access
    Human G-MDSCs are neutrophils at distinct maturation stages promoting tumor growth in breast cancer

    Meliha Mehmeti-Ajradini, Caroline Bergenfelz, Anna-Maria Larsson, Robert Carlsson, Kristian Riesbeck, Jonas Ahl, Helena Janols, Marlene Wullt, Anders Bredberg, Eva Källberg, Frida Björk Gunnarsdottir, Camilla Rydberg Millrud, Lisa Rydén, Gesine Paul, Niklas Loman, Jörgen Adolfsson, Ana Carneiro, Karin Jirström, Fredrika Killander, Daniel Bexell, Karin Leandersson

    Meliha Mehmeti-Ajradini ... Karin Leandersson

    Published 21 September 2020

    This study shows that immunosuppressive primary breast cancer patient–derived G-MDSCs (PMN-MDSCs) are neutrophils at a range of maturations stages, and provides in vivo evidence for that human G-MDSCs also promote tumor growth and myeloid immune cell exclusion.

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Issue Cover

Current Issue

Volume 3, No. 12
December 2020
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  • SOCS1 regulates immunotherapy in NSCLC
  • TMPRSS2 and furin activate SARS-CoV-2
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