Newest Articles
Myeloid transformation by MLL-ENL depends strictly on C/EBPThis publication shows that C/EBP (CCAAT enhancer–binding protein) transcription factors are mandatory for maintaining the myeloid leukemic phenotype, suggesting a therapeutic option by interfering with the non-oncogenic C/EBP dependence.
Leishmania-infected macrophages release extracellular vesicles that can promote lesion developmentMacrophages infected with Leishmania donovani release extracellular vesicles that are composed of parasite and host-derived molecules that have the potential to induce vascular changes in tissues.
Notch1 signaling determines the plasticity and function of fibroblasts in diabetic woundsNotch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds and may serve as a potential target for therapeutic intervention in diabetic wound healing.
Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activityPharmacological inhibition of ULK1 with multiple and distinct small molecules does not block autophagosome initiation but does impair autophagic flux.
Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradationThe balance between HIPK2-mediated phosphorylation and neddylation-dependent degradation controls spastin protein levels, revealing novel therapeutic targets for hereditary spastic paraplegia.
Chromosome instability induced by a single defined sister chromatid fusionNewly developed Fusion Visualization (FuVis) system reveals a single Xp sister chromatid fusion induces micronuclei formation, acentric chromosome fragments, and cell cycle instabilities.
Plasmodium DEH is ER-localized and crucial for oocyst mitotic division during malaria transmissionPlasmodium DEH localizes to the ER, with gene deletion resulting in degeneration of developing oocysts and complete ablation of sporogony in the mosquito midgut, blocking transmission.
Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytesUbiquitin signals the sorting of Cx43 into EVs, which is impaired during ischemia, resulting in decreased levels of Cx43 in cardiomyocyte-derived and circulating EVs from myocardial infarcted patients.
Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouseThe vital role of the splicing factor SRRM4 in vestibular and inner hair cells of the ear is inactivation of the gene repressor REST; however, in outer hair cells, SRRM4 is dispensable for REST inactivation, which SRRM3 accomplishes independently.
Brain is an endocrine organ through secretion and nuclear transfer of parathymosinThe hypothalamus and brain neurons orchestrate the secretion and nuclear transfer of PTMS which is neuroprotective against aging-related disorders.
