Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subjects
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research

User menu

  • My alerts

Search

  • Advanced search
Life Science Alliance
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research
  • My alerts
Life Science Alliance

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subjects
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Follow lsa Template on Twitter

Newest Articles

  • Myeloid transformation by <em>MLL</em>-<em>ENL</em> depends strictly on C/EBP
    Open Access
    Myeloid transformation by MLL-ENL depends strictly on C/EBP

    Radoslaw Wesolowski, Elisabeth Kowenz-Leutz, Karin Zimmermann, Dorothea Dörr, Maria Hofstätter, Robert K Slany, Alexander Mildner, Achim Leutz

    Radoslaw Wesolowski ... Achim Leutz

    Published 3 November 2020

    This publication shows that C/EBP (CCAAT enhancer–binding protein) transcription factors are mandatory for maintaining the myeloid leukemic phenotype, suggesting a therapeutic option by interfering with the non-oncogenic C/EBP dependence.

  • <em>Leishmania</em>-infected macrophages release extracellular vesicles that can promote lesion development
    Open Access
    Leishmania-infected macrophages release extracellular vesicles that can promote lesion development

    Anna Gioseffi, Tim Hamerly, Kha Van, Naixin Zhang, Rhoel R Dinglasan, Phillip A Yates, Peter E Kima

    Anna Gioseffi ... Peter E Kima

    Published 29 October 2020

    Macrophages infected with Leishmania donovani release extracellular vesicles that are composed of parasite and host-derived molecules that have the potential to induce vascular changes in tissues.

  • Notch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds
    Open Access
    Notch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds

    Hongwei Shao, Yan Li, Irena Pastar, Min Xiao, Rochelle Prokupets, Sophia Liu, Kerstin Yu, Roberto I Vazquez-Padron, Marjana Tomic-Canic, Omaida C Velazquez, Zhao-Jun Liu

    Hongwei Shao ... Zhao-Jun Liu

    Published 27 October 2020

    Notch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds and may serve as a potential target for therapeutic intervention in diabetic wound healing.

  • Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity
    Open Access
    Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity

    Maria Zachari, Marianna Longo, Ian G Ganley

    Maria Zachari ... Ian G Ganley

    Published 27 October 2020

    Pharmacological inhibition of ULK1 with multiple and distinct small molecules does not block autophagosome initiation but does impair autophagic flux.

  • Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation
    Open Access
    Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation

    Francesca Sardina, Alessandra Pisciottani, Manuela Ferrara, Davide Valente, Marialuisa Casella, Marco Crescenzi, Angelo Peschiaroli, Carlo Casali, Silvia Soddu, Andrew J Grierson, Cinzia Rinaldo

    Francesca Sardina ... Cinzia Rinaldo

    Published 26 October 2020

    The balance between HIPK2-mediated phosphorylation and neddylation-dependent degradation controls spastin protein levels, revealing novel therapeutic targets for hereditary spastic paraplegia.

  • Chromosome instability induced by a single defined sister chromatid fusion
    Open Access
    Chromosome instability induced by a single defined sister chromatid fusion

    Katsushi Kagaya, Naoto Noma-Takayasu, Io Yamamoto, Sanki Tashiro, Fuyuki Ishikawa, Makoto T Hayashi

    Katsushi Kagaya ... Makoto T Hayashi

    Published 26 October 2020

    Newly developed Fusion Visualization (FuVis) system reveals a single Xp sister chromatid fusion induces micronuclei formation, acentric chromosome fragments, and cell cycle instabilities.

  • <em>Plasmodium</em> DEH is ER-localized and crucial for oocyst mitotic division during malaria transmission
    Open Access
    Plasmodium DEH is ER-localized and crucial for oocyst mitotic division during malaria transmission

    David S Guttery, Rajan Pandey, David JP Ferguson, Richard J Wall, Declan Brady, Dinesh Gupta, Anthony A Holder, Rita Tewari

    David S Guttery ... Rita Tewari

    Published 26 October 2020

    Plasmodium DEH localizes to the ER, with gene deletion resulting in degeneration of developing oocysts and complete ablation of sporogony in the mosquito midgut, blocking transmission.

  • Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes
    Open Access
    Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes

    Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Saskia C de Jager, Monica Zuzarte, Cátia Ferreira, Pedro Cruz, Liliana Reis, Rui Baptista, Lino Gonçalves, Joost PG Sluijter, Henrique Girao

    Tania Martins-Marques ... Henrique Girao

    Published 23 October 2020

    Ubiquitin signals the sorting of Cx43 into EVs, which is impaired during ischemia, resulting in decreased levels of Cx43 in cardiomyocyte-derived and circulating EVs from myocardial infarcted patients.

  • Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse
    Open Access
    Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse

    Yoko Nakano, Susan Wiechert, Bernd Fritzsch, Botond Bánfi

    Yoko Nakano ... Botond Bánfi

    Published 21 October 2020

    The vital role of the splicing factor SRRM4 in vestibular and inner hair cells of the ear is inactivation of the gene repressor REST; however, in outer hair cells, SRRM4 is dispensable for REST inactivation, which SRRM3 accomplishes independently.

  • Brain is an endocrine organ through secretion and nuclear transfer of parathymosin
    Open Access
    Brain is an endocrine organ through secretion and nuclear transfer of parathymosin

    Bin Yu, Yizhe Tang, Dongsheng Cai

    Bin Yu ... Dongsheng Cai

    Published 21 October 2020

    The hypothalamus and brain neurons orchestrate the secretion and nuclear transfer of PTMS which is neuroprotective against aging-related disorders.

Pages

  • Previous
  • Next
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • …
  • 42
Issue Cover

Current Issue

Volume 3, No. 12
December 2020
  • Table of Contents
  • Cover (PDF)
  • About the Cover
  • Masthead (PDF)
Sign up for alerts
  • Most Read
Loading
  • SOCS1 regulates immunotherapy in NSCLC
  • TMPRSS2 and furin activate SARS-CoV-2
  • γδ T-cell single-cell RNA-seq
  • Brown preadipocyte heterogeneity
  • Predicting cells position from single-cell transcriptomics
More...
Advertisement

EMBO Press LogoRockefeller University Press LogoCold Spring Harbor Logo

Content

  • Home
  • Newest Articles
  • Current Issue
  • Archive
  • Subject Collections

For Authors

  • Submit a Manuscript
  • Author Guidelines
  • License, copyright, Fee

Other Services

  • Alerts
  • Twitter
  • RSS Feeds

More Information

  • Editors & Staff
  • Reviewer Guidelines
  • Feedback
  • Licensing and Reuse
  • Privacy Policy

ISSN: 2575-1077
© 2021 Life Science Alliance LLC

Life Science Alliance is registered as a trademark in the U.S. Patent and Trade Mark Office and in the European Union Intellectual Property Office.