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Newest Articles

  • Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturation
    Open Access
    Maternal circulating miRNAs that predict infant FASD outcomes influence placental maturation

    Alexander M Tseng, Amanda H Mahnke, Alan B Wells, Nihal A Salem, Andrea M Allan, Victoria HJ Roberts, Natali Newman, Nicole AR Walter, Christopher D Kroenke, Kathleen A Grant, Lisa K Akison, Karen M Moritz, Christina D Chambers, Rajesh C Miranda, Collaborative Initiative on Fetal Alcohol Spectrum Disorders

    Alexander M Tseng ... Collaborative Initiative on Fetal Alcohol Spectrum Disorders

    Published 4 March 2019

    Maternal gestational circulating microRNAs, predictive of adverse infant outcomes, including growth deficits, following prenatal alcohol exposure, contribute to placental pathology by impairing the EMT pathway in trophoblasts.

  • Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis
    Open Access
    Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis

    Florian Noack, Abhijeet Pataskar, Martin Schneider, Frank Buchholz, Vijay K Tiwari, Federico Calegari

    Florian Noack ... Federico Calegari

    Published 27 February 2019

    This work describes the dynamics of DNA modifications in specific cell types of the developing mammalian cortex. By providing a new method to manipulate this process in vivo, it is shown how this process can influence brain formation.

  • Worldwide genetic variation of the IGHV and TRBV immune receptor gene families in humans
    Open Access
    Worldwide genetic variation of the IGHV and TRBV immune receptor gene families in humans

    Shishi Luo, Jane A Yu, Heng Li, Yun S Song

    Shishi Luo ... Yun S Song

    Published 26 February 2019

    This article presents a comprehensive study of the IGHV and TRBV gene families in a globally diverse sample of humans and shows that the two gene families exhibit starkly different patterns of variation.

  • FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress
    Open Access
    FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress

    Maria Isabel Martinez-Macias, Duncan AQ Moore, Ryan L Green, Fernando Gomez-Herreros, Marcel Naumann, Andreas Hermann, Philip Van Damme, Majid Hafezparast, Keith W Caldecott

    Maria Isabel Martinez-Macias ... Keith W Caldecott

    Published 26 February 2019

    This work shows that the ALS-associated protein FUS is a component of the cellular response to transcriptional stress induced by topoisomerase I–induced DNA breakage, thereby accumulating at sites of nucleolar rRNA synthesis.

  • Main constraints for RNAi induced by expressed long dsRNA in mouse cells
    Open Access
    Main constraints for RNAi induced by expressed long dsRNA in mouse cells

    Tomas Demeter, Michaela Vaskovicova, Radek Malik, Filip Horvat, Josef Pasulka, Eliska Svobodova, Matyas Flemr, Petr Svoboda

    Tomas Demeter ... Petr Svoboda

    Published 26 February 2019

    A systematic survey of dsRNA expression in mouse fibroblasts and embryonic stem cells shows main constraints for RNAi. RNAi activity depends on the initial Dicer cleavage of dsRNA, having implications for the evolution of mammalian RNAi functions.

  • MiR-146a wild-type 3′ sequence identity is dispensable for proper innate immune function in vivo
    Open Access
    MiR-146a wild-type 3′ sequence identity is dispensable for proper innate immune function in vivo

    Grant Bertolet, Natee Kongchan, Rebekah Miller, Ravi K Patel, Antrix Jain, Jong Min Choi, Alexander B Saltzman, Amber Christenson, Sung Yun Jung, Anna Malovannaya, Andrew Grimson, Joel R Neilson

    Grant Bertolet ... Joel R Neilson

    Published 18 February 2019

    Mice engineered to express an allele of a mammalian microRNA in which the 3′ paring specificity of the mature miRNA is robustly altered are phenotypically indistinguishable from mice with the wild-type allele.

  • Mucosa-associated microbiota drives pathogenic functions in IBD-derived intestinal iNKT cells
    Open Access
    Mucosa-associated microbiota drives pathogenic functions in IBD-derived intestinal iNKT cells

    Claudia Burrello, Gabriella Pellegrino, Maria Rita Giuffrè, Giulia Lovati, Ilaria Magagna, Alice Bertocchi, Fulvia Milena Cribiù, Francesca Boggio, Fiorenzo Botti, Elena Trombetta, Laura Porretti, Antonio Di Sabatino, Maurizio Vecchi, Maria Rescigno, Flavio Caprioli, Federica Facciotti

    Claudia Burrello ... Federica Facciotti

    Published 13 February 2019

    Pro-inflammatory iNKT cells are enriched in IBD patients’ lamina propria. Exposure to the mucosa-associated microbiota drives their activation, inducing pathogenic activities against the epithelium.

  • Epithelial polarization in 3D matrix requires DDR1 signaling to regulate actomyosin contractility
    Open Access
    Epithelial polarization in 3D matrix requires DDR1 signaling to regulate actomyosin contractility

    Pia Pernille Søgaard, Noriko Ito, Nanami Sato, Yasuyuki Fujita, Karl Matter, Yoshifumi Itoh

    Pia Pernille Søgaard ... Yoshifumi Itoh

    Published 13 February 2019

    For epithelial cells to establish epithelial polarity in a 3D matrix, signaling of a collagen receptor tyrosine kinase, DDR1, plays a crucial role. DDR1 signaling controls actomyosin contractility at the cell–cell junction through suppression of ROCK activity.

  • Opposing Roles of apolipoprotein E in aging and neurodegeneration
    Open Access
    Opposing Roles of apolipoprotein E in aging and neurodegeneration

    Eloise Hudry, Jacob Klickstein, Claudia Cannavo, Rosemary Jackson, Alona Muzikansky, Sheetal Gandhi, David Urick, Taylie Sargent, Lauren Wrobleski, Allyson D Roe, Steven S Hou, Kishore V Kuchibhotla, Rebecca A Betensky, Tara Spires-Jones, Bradley T Hyman

    Eloise Hudry ... Bradley T Hyman

    Published 13 February 2019

    This study investigates how APOE modulates neuronal function integrity during normal aging and in the context of amyloidosis. This work demonstrates that APOE is a necessary partner of Aβ-dependent neuronal dysfunction and synaptotoxicity but also preserves neuronal network during aging.

  • An essential role for α4A-tubulin in platelet biogenesis
    Open Access
    An essential role for α4A-tubulin in platelet biogenesis

    Catherine Strassel, Maria M Magiera, Arnaud Dupuis, Morgane Batzenschlager, Agnès Hovasse, Irina Pleines, Paul Guéguen, Anita Eckly, Sylvie Moog, Léa Mallo, Quentin Kimmerlin, Stéphane Chappaz, Jean-Marc Strub, Natarajan Kathiresan, Henri de la Salle, Alain Van Dorsselaer, Claude Ferec, Jean-Yves Py, Christian Gachet, Christine Schaeffer-Reiss, Benjamin T Kile, Carsten Janke, François Lanza

    Catherine Strassel ... François Lanza

    Published 13 February 2019

    Alpha4A-tubulin is the predominant α-tubulin isotype in platelets. Mutations in α4A-tubulin cause abnormal platelet biogenesis and marginal band formation in mice and in a patient, establishing an essential role of this tubulin isotype.

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Issue Cover

Current Issue

Volume 4, No. 2
February 2021
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  • TMPRSS2 and furin activate SARS-CoV-2
  • SOCS1 regulates immunotherapy in NSCLC
  • Mutant RUNX1 perturbs differentiation
  • A FIJI macro for quantifying fibrillar patterns
  • Cytoplasmic cyclin A2 initiates PLK1 activation
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