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Newest Articles

  • An extracellular matrix protein promotes anillin-dependent processes in the <em>Caenorhabditis elegans</em> germline
    Open Access
    An extracellular matrix protein promotes anillin-dependent processes in the Caenorhabditis elegans germline

    Hongxia Lan, Xinyan Wang, Ling Jiang, Jianjian Wu, Xuan Wan, Lidan Zeng, Dandan Zhang, Yiyan Lin, Chunhui Hou, Shian Wu, Yu Chung Tse

    Hongxia Lan ... Yu Chung Tse

    Published 15 April 2019

    The extracellular matrix protein Hemicentin (HIM-4) is an extracellular factor that regulates anillin (ANI-1) for germ cell membrane stabilization and contractile ring formation in C. elegans germline cells.

  • Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction
    Open Access
    Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction

    Sophia von Stockum, Alvaro Sanchez-Martinez, Samantha Corrà, Joy Chakraborty, Elena Marchesan, Lisa Locatello, Caterina Da Rè, Paola Cusumano, Federico Caicci, Vanni Ferrari, Rodolfo Costa, Luigi Bubacco, Maria Berica Rasotto, Ildiko Szabo, Alexander J Whitworth, Luca Scorrano, Elena Ziviani

    Sophia von Stockum ... Elena Ziviani

    Published 15 April 2019

    Aberrant mitochondrial dynamics contribute to disease conditions. Genetic and pharmacological inhibition of USP8 ameliorates mitochondrial phenotypes deriving from loss of function of Drosophila PINK1 and Parkin.

  • Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress
    Open Access
    Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress

    David F Moreno, Eva Parisi, Galal Yahya, Federico Vaggi, Attila Csikász-Nagy, Martí Aldea

    David F Moreno ... Martí Aldea

    Published 15 April 2019

    Growth and cell-cycle entry compete for multifunctional chaperones subjugating the critical size and proliferation to the growth potential of the cell.

  • Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity
    Open Access
    Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity

    Sara Priego Moreno, Rebecca M Jones, Divyasree Poovathumkadavil, Shaun Scaramuzza, Agnieszka Gambus

    Sara Priego Moreno ... Agnieszka Gambus

    Published 12 April 2019

    Analysis of the mitotic replisome disassembly pathway in X. laevis egg extract shows that any replisomes retained on chromatin past S-phase are unloaded through formation of K6- and K63-linked ubiquitin chains on Mcm7 by TRAIP ubiquitin ligase and p97/VCP activity.

  • Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association
    Open Access
    Human CST suppresses origin licensing and promotes AND-1/Ctf4 chromatin association

    Yilin Wang, Kathryn S Brady, Benjamin P Caiello, Stephanie M Ackerson, Jason A Stewart

    Yilin Wang ... Jason A Stewart

    Published 12 April 2019

    This study suggests a novel role of the telomere-associated human CST complex in suppressing origin licensing, through interactions with MCM, while promoting the recruitment of AND-1 and DNA polymerase alpha for replisome formation.

  • A network of human functional gene interactions from knockout fitness screens in cancer cells
    Open Access
    A network of human functional gene interactions from knockout fitness screens in cancer cells

    Eiru Kim, Merve Dede, Walter F Lenoir, Gang Wang, Sanjana Srinivasan, Medina Colic, Traver Hart

    Eiru Kim ... Traver Hart

    Published 12 April 2019

    The function of human genes can be strongly inferred from their knockout fitness profiles across hundreds of CRISPR screens, illuminating the modular organization of the cell.

  • CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth
    Open Access
    CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth

    Sehee Choi, Hyun-Yi Kim, Pu-Hyeon Cha, Seol Hwa Seo, Chulho Lee, Yejoo Choi, Wookjin Shin, Yunseok Heo, Gyoonhee Han, Weontae Lee, Kang-Yell Choi

    Sehee Choi ... Kang-Yell Choi

    Published 10 April 2019

    Inhibition of the CXXC5–DVL interaction is a potential therapeutic strategy for height enhancement of children with growth retardation.

  • m<sup>6</sup>A-mRNA methylation regulates cardiac gene expression and cellular growth
    Open Access
    m6A-mRNA methylation regulates cardiac gene expression and cellular growth

    Vivien Kmietczyk, Eva Riechert, Laura Kalinski, Etienne Boileau, Ellen Malovrh, Brandon Malone, Agnieszka Gorska, Christoph Hofmann, Eshita Varma, Lonny Jürgensen, Verena Kamuf-Schenk, Janine Altmüller, Rewati Tappu, Martin Busch, Patrick Most, Hugo A Katus, Christoph Dieterich, Mirko Völkers

    Vivien Kmietczyk ... Mirko Völkers

    Published 9 April 2019

    This study provides evidence that m6A methylation is dynamically regulated during human and murine cardiac disease and highlights an important role of the m6A methylase Mettl3 in regulating cardiac growth by gene expression control.

  • Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control <em>Clostridium difficile</em> colitis
    Open Access
    Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis

    Ruixue Liu, Richard Moriggl, Dongsheng Zhang, Haifeng Li, Rebekah Karns, Hai-Bin Ruan, Haitao Niu, Christopher Mayhew, Carey Watson, Hansraj Bangar, Sang-wook Cha, David Haslam, Tongli Zhang, Shila Gilbert, Na Li, Michael Helmrath, James Wells, Lee Denson, Xiaonan Han

    Ruixue Liu ... Xiaonan Han

    Published 4 April 2019

    STAT5 controls the intestinal epithelial stem cell niche by regulating Wnt/β-catenin signaling, and lack of active pYSTAT5 induces Clostridium difficile infection. STAT5 may be a transcription factor that restricts niche cell differentiation.

  • ROS amplification drives mouse spermatogonial stem cell self-renewal
    Open Access
    ROS amplification drives mouse spermatogonial stem cell self-renewal

    Hiroko Morimoto, Mito Kanastu-Shinohara, Narumi Ogonuki, Satoshi Kamimura, Atsuo Ogura, Chihiro Yabe-Nishimura, Yoshifumi Mori, Takeshi Morimoto, Satoshi Watanabe, Kinya Otsu, Takuya Yamamoto, Takashi Shinohara

    Hiroko Morimoto ... Takashi Shinohara

    Published 2 April 2019

    Although reactive oxygen species (ROS) are required for spermatogonial stem cell (SSC) self-renewal, the mechanism has remained unknown. We show that SSC self-renewal signals activate MAPK14/MAPK7 pathway to induce nuclear translocation of BCL6B and activation of NOX1.

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Volume 4, No. 3
March 2021
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