Newest Articles
Distinctive features of lincRNA gene expression suggest widespread RNA-independent functionsCombining single-cell RNA-seq of mouse ESCs and NPCs, lincRNA gene deletions, conditional RNA depletion, and nuclear exosome profiling distinguishes RNA-dependent and RNA-independent lincRNA gene activities.
Pericytes promote skin regeneration by inducing epidermal cell polarity and planar cell divisionsThis study reveals that mesenchymal stem cell–like dermal pericytes increase the number of epidermal stem and progenitor cells in human skin by promoting planar cell divisions within the proliferative compartment, without compromising skin differentiation—most likely via paracrine BMP-2 secretion.
Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activityExpression of the Vnn1 pantetheinase by sarcomas is tumor suppressive by limiting the use of aerobic glycolysis for growth and rescuing mitochondrial activity through CoA regeneration.
Proteins of generalist and specialist pathogens differ in their amino acid compositionPrimitive amino acids and disorder content in secreted proteins are distinctively enriched in generalist compared with host-specific pathogens.
Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1The authors apply telomeric chromatin analysis to identify factors that accumulate at telomeres during cellular transformation, promoting telomere replication and repair and counteracting oncogene-borne telomere replication stress.
Role of Cnot6l in maternal mRNA turnoverMice lacking Cnot6l, a deadenylase component of the CCR4–NOT complex, are viable, but females have ∼40% smaller litters. Cnot6l is a maternal-effect gene acting in maternal mRNA degradation.
Immunoediting is not a primary transformation event in a murine model of MLL-ENL AMLUsing a conditional model of MLL-ENL–driven AML, Dudenhöffer-Pfeifer and Bryder show that NK cell and adaptive immunity influences little on leukemia initiation from normal cells. The data argue against immune escape as a universal primary transformation event in AML.
The histone chaperone FACT modulates nucleosome structure by tethering its componentsThe histone chaperone FACT functions by tethering partial components of the nucleosome, thereby assisting nucleosome disassembly and reassembly during transcription.
Dynamic m6A methylation facilitates mRNA triaging to stress granulesm6A modification in the 5′ vicinity of the coding sequence of transcripts provides a selective mechanism for triaging mRNAs to stress granules and is mediated by the YTHDF3 “reader” protein.
DNA polymerase ζ deficiency causes impaired wound healing and stress-induced skin pigmentationMice harboring DNA polymerase ζ–defective keratinocytes are shown to have a defect in wound healing and a striking p53-dependent migration of melanocytes to the skin following UV radiation or wounding.
