Newest Articles
The histone chaperone FACT modulates nucleosome structure by tethering its componentsThe histone chaperone FACT functions by tethering partial components of the nucleosome, thereby assisting nucleosome disassembly and reassembly during transcription.
Dynamic m6A methylation facilitates mRNA triaging to stress granulesm6A modification in the 5′ vicinity of the coding sequence of transcripts provides a selective mechanism for triaging mRNAs to stress granules and is mediated by the YTHDF3 “reader” protein.
DNA polymerase ζ deficiency causes impaired wound healing and stress-induced skin pigmentationMice harboring DNA polymerase ζ–defective keratinocytes are shown to have a defect in wound healing and a striking p53-dependent migration of melanocytes to the skin following UV radiation or wounding.
Molecular analysis of human Ero1 reveals novel regulatory mechanisms for oxidative protein foldingThis study reveals novel regulatory mechanisms for human Ero1α and Ero1β, including cooperativity for oxygen binding and complex formation with PDI via a novel mixed disulfide linkage.
JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell–derived neural progenitors and cortical neuronsMolecular and cellular profiling of patient-specific neural cell types provides suggestions for the involvement of JIP2 in the neurodevelopmental disorder Phelan–McDermid syndrome.
Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repairThis study reveals that the synaptonemal complex protein SYCE2 potentiates ataxia telangiectasia mutated–mediated DNA double-strand break repair by dissociating HP1α from trimethylated histone H3 lysine 9 in somatic cells.
Recruitment of ubiquitin-activating enzyme UBA1 to DNA by poly(ADP-ribose) promotes ATR signallingHuman but not yeast UBA1 binds poly(ADP-ribose) polymers via a solvent-exposed and positively charged patch. Poly(ADP-ribose) polymerase 1–dependent recruitment of UBA1 to DNA ensures ataxia-telangiectasia and RAD3-related activation.
Chronic platelet-derived growth factor receptor signaling exerts control over initiation of protein translation in gliomaUsing phospho-proteomics in a new model of malignant glioma, we reveal that clinically relevant, chronic PDGFRα signaling differs considerably from acute receptor stimulation and unveils previously unrecognized control over key elements of the translation initiation machinery.
Silica-based solid-phase extraction of cross-linked nucleic acid–bound proteinsThe 2C method allows the rapid and straightforward isolation of nucleic acid–protein complexes, greatly simplifying downstream applications for the study of DNA– and RNA–protein interactions.
DHX15 regulates CMTR1-dependent gene expression and cell proliferationDHX15 helicase regulates CMTR1-dependent first transcribed nucleotide ribose O-2 methylation.
