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Newest Articles

  • The hypoxia-response pathway modulates RAS/MAPK–mediated cell fate decisions in <em>Caenorhabditis elegans</em>
    Open Access
    The hypoxia-response pathway modulates RAS/MAPK–mediated cell fate decisions in Caenorhabditis elegans

    Sabrina Maxeiner, Judith Grolleman, Tobias Schmid, Jan Kammenga, Alex Hajnal

    Sabrina Maxeiner ... Alex Hajnal

    Published 24 May 2019

    Atmospheric oxygen levels modulate the RAS/MAPK signaling pathway in the nematode Caenorhabditis elegans through a cross-talk between the DELTA/NOTCH and hypoxia signaling pathways. These mechanisms may permit the animals to adapt their development to changes in the environment.

  • Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
    Open Access
    Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration

    Mariana Aparecida Brunini Rosales, Daisy Y Shu, Jared Iacovelli, Magali Saint-Geniez

    Mariana Aparecida Brunini Rosales ... Magali Saint-Geniez

    Published 17 May 2019

    Sustained loss of PGC-1α in RPE cells triggers mitochondrial/autophagic dysfunction and oxidative damage resulting in epithelial dedifferentiation and mesenchymal transition. RPE dysfunction caused by deletion of the PGC-1 coactivators in vivo causes retinal degeneration.

  • An N-terminal–truncated isoform of FAM134B (FAM134B-2) regulates starvation-induced hepatic selective ER-phagy
    Open Access
    An N-terminal–truncated isoform of FAM134B (FAM134B-2) regulates starvation-induced hepatic selective ER-phagy

    Shohei Kohno, Yuji Shiozaki, Audrey L Keenan, Shinobu Miyazaki-Anzai, Makoto Miyazaki

    Shohei Kohno ... Makoto Miyazaki

    Published 17 May 2019

    This study has identified a novel truncated isoform of FAM134B (FAM134B-2) that regulates starvation-induced selective ER-phagy of secretory proteins such as ApoCIII through the activation of C/EBPβ.

  • MicroRNA-155 is essential for the optimal proliferation and survival of plasmablast B cells
    Open Access
    MicroRNA-155 is essential for the optimal proliferation and survival of plasmablast B cells

    Giuseppina Arbore, Tom Henley, Laura Biggins, Simon Andrews, Elena Vigorito, Martin Turner, Rebecca Leyland

    Giuseppina Arbore ... Rebecca Leyland

    Published 16 May 2019

    Tracking antigen-specific B cells in vivo since the onset of antigen stimulation shows that miR-155 regulates the early expansion of B-blasts and later on the optimal proliferation and survival of plasmablasts in a B-cell–intrinsic manner.

  • Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3
    Open Access
    Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3

    Chang-Min Lee, Chuan-Hua He, Jin Wook Park, Jae Hyun Lee, Suchita Kamle, Bing Ma, Bedia Akosman, Roberto Cotez, Emily Chen, Yang Zhou, Erica L Herzog, Changwan Ryu, Xueyan Peng, Ivan O Rosas, Sergio Poli, Carol Feghali Bostwick, Augustine M Choi, Jack A Elias, Chun Geun Lee

    Chang-Min Lee ... Chun Geun Lee

    Published 13 May 2019

    Chitinase 1 (CHIT1) plays a role in the pathogenesis of pulmonary fibrosis by modulating canonical and noncanonical TGF-β signaling via interaction with TGFBRAP1 and FOXO3. These findings highlight the CHIT1/SMAD7 axis as a potential biomarker and therapeutic target of pulmonary fibrosis.

  • Cellular response upon proliferation in the presence of an active mitotic checkpoint
    Open Access
    Cellular response upon proliferation in the presence of an active mitotic checkpoint

    Andrea Corno, Elena Chiroli, Fridolin Gross, Claudio Vernieri, Vittoria Matafora, Stefano Maffini, Marco Cosentino Lagomarsino, Angela Bachi, Andrea Ciliberto

    Andrea Corno ... Andrea Ciliberto

    Published 8 May 2019

    Cells that replicate with an active mitotic checkpoint remain capable to mount multiple times an efficient arrest, are bigger than unperturbed cells, rely more heavily on Cdh1, and have an altered protein expression profile.

  • Development of a new monoclonal antibody specific to mouse Vγ6 chain
    Open Access
    Development of a new monoclonal antibody specific to mouse Vγ6 chain

    Shinya Hatano, Xin Tun, Naoto Noguchi, Dan Yue, Hisakata Yamada, Xun Sun, Mitsuru Matsumoto, Yasunobu Yoshikai

    Shinya Hatano ... Yasunobu Yoshikai

    Published 7 May 2019

    Using a novel mAb specific to Vγ6 TCR, we find Vγ6+ γδT cells are located in association with medullary thymic epithelial cells and play crucial roles in protection against Klebsiella pneumoniae infection but are pathogenic in psoriasis-like dermatitis in agreement with earlier studies.

  • Noncoding AUG circRNAs constitute an abundant and conserved subclass of circles
    Open Access
    Noncoding AUG circRNAs constitute an abundant and conserved subclass of circles

    Lotte VW Stagsted, Katrine M Nielsen, Iben Daugaard, Thomas B Hansen

    Lotte VW Stagsted ... Thomas B Hansen

    Published 26 April 2019

    AUG circRNAs are highly abundant and conserved with an Alu-independent mode of biogenesis. Although AUG circRNAs contain the N-terminal ORFs, no evidence supports translation of these circRNAs.

  • Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity
    Open Access
    Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity

    Rebecca V Stevens, Diego Esposito, Katrin Rittinger

    Rebecca V Stevens ... Katrin Rittinger

    Published 26 April 2019

    This study shows that members of the class VI TRIM E3 ligase family contain monomeric RING domains and display no ligase activity and may require additional regulatory events to promote ubiquitination.

  • The impact of poly-A microsatellite heterologies in meiotic recombination
    Open Access
    The impact of poly-A microsatellite heterologies in meiotic recombination

    Angelika Heissl, Andrea J Betancourt, Philipp Hermann, Gundula Povysil, Barbara Arbeithuber, Andreas Futschik, Thomas Ebner, Irene Tiemann-Boege

    Angelika Heissl ... Irene Tiemann-Boege

    Published 25 April 2019

    Meiosis strongly influences the transmission and evolution of heterozygous poly-A repeats as measured experimentally in a large collection of single recombination products in a human hotspot.

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Volume 4, No. 3
March 2021
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