Newest Articles
- The hypoxia-response pathway modulates RAS/MAPK–mediated cell fate decisions in Caenorhabditis elegans
Atmospheric oxygen levels modulate the RAS/MAPK signaling pathway in the nematode Caenorhabditis elegans through a cross-talk between the DELTA/NOTCH and hypoxia signaling pathways. These mechanisms may permit the animals to adapt their development to changes in the environment.
- Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
Sustained loss of PGC-1α in RPE cells triggers mitochondrial/autophagic dysfunction and oxidative damage resulting in epithelial dedifferentiation and mesenchymal transition. RPE dysfunction caused by deletion of the PGC-1 coactivators in vivo causes retinal degeneration.
- An N-terminal–truncated isoform of FAM134B (FAM134B-2) regulates starvation-induced hepatic selective ER-phagy
This study has identified a novel truncated isoform of FAM134B (FAM134B-2) that regulates starvation-induced selective ER-phagy of secretory proteins such as ApoCIII through the activation of C/EBPβ.
- MicroRNA-155 is essential for the optimal proliferation and survival of plasmablast B cells
Tracking antigen-specific B cells in vivo since the onset of antigen stimulation shows that miR-155 regulates the early expansion of B-blasts and later on the optimal proliferation and survival of plasmablasts in a B-cell–intrinsic manner.
- Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3
Chitinase 1 (CHIT1) plays a role in the pathogenesis of pulmonary fibrosis by modulating canonical and noncanonical TGF-β signaling via interaction with TGFBRAP1 and FOXO3. These findings highlight the CHIT1/SMAD7 axis as a potential biomarker and therapeutic target of pulmonary fibrosis.
- Cellular response upon proliferation in the presence of an active mitotic checkpoint
Cells that replicate with an active mitotic checkpoint remain capable to mount multiple times an efficient arrest, are bigger than unperturbed cells, rely more heavily on Cdh1, and have an altered protein expression profile.
- Development of a new monoclonal antibody specific to mouse Vγ6 chain
Using a novel mAb specific to Vγ6 TCR, we find Vγ6+ γδT cells are located in association with medullary thymic epithelial cells and play crucial roles in protection against Klebsiella pneumoniae infection but are pathogenic in psoriasis-like dermatitis in agreement with earlier studies.
- Noncoding AUG circRNAs constitute an abundant and conserved subclass of circles
AUG circRNAs are highly abundant and conserved with an Alu-independent mode of biogenesis. Although AUG circRNAs contain the N-terminal ORFs, no evidence supports translation of these circRNAs.
- Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity
This study shows that members of the class VI TRIM E3 ligase family contain monomeric RING domains and display no ligase activity and may require additional regulatory events to promote ubiquitination.
- The impact of poly-A microsatellite heterologies in meiotic recombination
Meiosis strongly influences the transmission and evolution of heterozygous poly-A repeats as measured experimentally in a large collection of single recombination products in a human hotspot.