Newest Articles
Interaction modulation through arrays of clustered methyl-arginine protein modificationsExtensively modifiable arrays of clustered arginines in a large set of human proteins function as regulatory protein interaction platforms. Quantitative immunoprecipitation assays defined two distinct cumulative binding mechanisms operating across an array of 18 methyl-arginine motifs in SYNCRIP.
S-phase transcriptional buffering quantified on two different promotersTranscriptional buffering enforced during DNA replication shows that histone acetylation governs the homeostasis process and can also restrict promoters from reaching maximum transcriptional potential
CARM1 methylates MED12 to regulate its RNA-binding abilityCARM1 methylates MED12 at arginine 1899 to generate a TDRD3 binding site, which in turn regulates the ability of mediator to interact with activating ncRNAs and modulate gene expression.
Identification of Plasmodium GAPDH epitopes for generation of antibodies that inhibit malaria infectionThis study reports on the identification of two Plasmodium GAPDH epitope peptides that are responsible for sporozoite–Kupffer cell interaction and act as antigens against malaria infection.
Transposon silencing in the Drosophila female germline is essential for genome stability in progeny embryosSuppression of transposons by the Piwi-interacting RNA biogenesis factor Vasa in the supporting nurse cells is essential to prevent their accumulation in the developing oocyte, ensuring proper Drosophila embryonic development.
Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethalityMouse embryos with an ablated ability of integrins to bind laminins are still able to form basement membranes, but die just after implantation because of deficient extraembryonic development.
MBNL1 alternative splicing isoforms play opposing roles in cancerMBNL1 proteins lacking exon 7 (−ex7) are antisurvival factors with tumor suppressive role that cancer cells tend to down-regulate in favor of MBNL +ex7 isoforms.
Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translationThis study uses polysomal RNA sequencing to show that the translational efficiency of specific mRNA changes in long-lived Caenorhabditis elegans with reduced ubiquinone synthesis.
Chromatin-mediated translational control is essential for neural cell fate specificationChd5 loss links the up-regulation of ribosomal genes to enhanced translation, causing the untimely production of a master transcription factor that unleashes stem cells and alters cell fate.
Dynamic reorganisation of intermediate filaments coordinates early B-cell activationThis study examines the role of vimentin, a type III intermediate filament, in B-cell function using a combination of in vitro and in vivo assays, including super-resolution microscopic techniques.
