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Newest Articles

  • Robust repression of tRNA gene transcription during stress requires protein arginine methylation
    Open Access
    Robust repression of tRNA gene transcription during stress requires protein arginine methylation

    Richoo B Davis, Neah Likhite, Christopher A Jackson, Tao Liu, Michael C Yu

    Richoo B Davis ... Michael C Yu

    Published 3 June 2019

    This work examines how protein arginine methylation of Rpc31, a subunit of RNA Pol III, promotes negative regulation of tRNA biogenesis in the context of cellular stress.

  • Opposing functions of F-BAR proteins in neuronal membrane protrusion, tubule formation, and neurite outgrowth
    Open Access
    Opposing functions of F-BAR proteins in neuronal membrane protrusion, tubule formation, and neurite outgrowth

    Kendra L Taylor, Russell J Taylor, Karl E Richters, Brandon Huynh, Justin Carrington, Maeve E McDermott, Rebecca L Wilson, Erik W Dent

    Kendra L Taylor ... Erik W Dent

    Published 3 June 2019

    Neurite formation is a fundamental antecedent to axon and dendrite formation, but the mechanisms that underlie this important process are poorly characterized. Here, we demonstrate that two F-BAR proteins, CIP4 and FBP17, have opposing functions in early cortical neuron development.

  • ATP hydrolysis by KaiC promotes its KaiA binding in the cyanobacterial circadian clock system
    Open Access
    ATP hydrolysis by KaiC promotes its KaiA binding in the cyanobacterial circadian clock system

    Yasuhiro Yunoki, Kentaro Ishii, Maho Yagi-Utsumi, Reiko Murakami, Susumu Uchiyama, Hirokazu Yagi, Koichi Kato

    Yasuhiro Yunoki ... Koichi Kato

    Published 3 June 2019

    ATP hydrolysis in the KaiC hexamer triggers the exposure of its C-terminal segments into the solvent so as to capture KaiA, providing mechanistic insights into the circadian periodicity regulation.

  • The <em>S</em>. Typhi effector StoD is an E3/E4 ubiquitin ligase which binds K48- and K63-linked diubiquitin
    Open Access
    The S. Typhi effector StoD is an E3/E4 ubiquitin ligase which binds K48- and K63-linked diubiquitin

    Melanie A McDowell, Alexander MP Byrne, Elli Mylona, Rebecca Johnson, Agnes Sagfors, Valerie F Crepin, Susan Lea, Gad Frankel

    Melanie A McDowell ... Gad Frankel

    Published 29 May 2019

    Salmonella Typhi is estimated to cause 100,000–200,000 deaths annually, yet its infection strategy remains elusive. This article reports of the first Typhi-specific effector, which has an E3/E4 ubiquitin ligase activity and can uniquely bind K48- and K63-linked diubiquitin.

  • Open Access
    Correction: Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration

    Mariana Aparecida Brunini Rosales, Daisy Y Shu, Jared Iacovelli, Magali Saint-Geniez

    Mariana Aparecida Brunini Rosales ... Magali Saint-Geniez

    Published 29 May 2019
  • PKAc is not required for the preerythrocytic stages of <em>Plasmodium berghei</em>
    Open Access
    PKAc is not required for the preerythrocytic stages of Plasmodium berghei

    Hadi Hasan Choudhary, Roshni Gupta, Satish Mishra

    Hadi Hasan Choudhary ... Satish Mishra

    Published 29 May 2019

    The mutant salivary gland sporozoites lacking PKAc are able to glide, invade hepatocytes, and mature into hepatic merozoites, which release successfully from the merosome, however, fail to initiate blood stage infection when inoculated into mice.

  • The m<sup>6</sup>A pathway protects the transcriptome integrity by restricting RNA chimera formation in plants
    Open Access
    The m6A pathway protects the transcriptome integrity by restricting RNA chimera formation in plants

    Dominique Pontier, Claire Picart, Moaine El Baidouri, François Roudier, Tao Xu, Sylvie Lahmy, Christel Llauro, Jacinthe Azevedo, Michèle Laudié, Aurore Attina, Christophe Hirtz, Marie-Christine Carpentier, Lisha Shen, Thierry Lagrange

    Dominique Pontier ... Thierry Lagrange

    Published 29 May 2019

    This study reveals that an m6A-assisted polyadenylation pathway comprising conserved m6A writer proteins and a plant-specific m6A reader contributes to transcriptome integrity in Arabidopsis thaliana by restricting RNA chimera formation at rearranged loci.

  • Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti–PD-1 response in NSCLC
    Open Access
    Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti–PD-1 response in NSCLC

    Bonnie L Bullock, Abigail K Kimball, Joanna M Poczobutt, Alexander J Neuwelt, Howard Y Li, Amber M Johnson, Jeff W Kwak, Emily K Kleczko, Rachael E Kaspar, Emily K Wagner, Katharina Hopp, Erin L Schenk, Mary CM Weiser-Evans, Eric T Clambey, Raphael A Nemenoff

    Bonnie L Bullock ... Raphael A Nemenoff

    Published 27 May 2019

    Using an immunocompetent mouse model of NSCLC, this study demonstrates that tumor-intrinsic response to IFNγ determines response to anti–PD-1 through alterations in the tumor microenvironment.

  • Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules
    Open Access
    Molecular characterization of CHAD domains as inorganic polyphosphate-binding modules

    Laura Lorenzo-Orts, Ulrich Hohmann, Jinsheng Zhu, Michael Hothorn

    Laura Lorenzo-Orts ... Michael Hothorn

    Published 27 May 2019

    A domain of unknown function termed CHAD, present in all kingdoms of life, is characterized as a specific inorganic polyphosphate-binding domain.

  • Rate of brain aging and <em>APOE ε4</em> are synergistic risk factors for Alzheimer’s disease
    Open Access
    Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

    Christin A Glorioso, Andreas R Pfenning, Sam S Lee, David A Bennett, Etienne L Sibille, Manolis Kellis, Leonard P Guarente

    Christin A Glorioso ... Leonard P Guarente

    Published 27 May 2019

    This study describes a gauge for brain aging predictive of cognitive decline and Alzheimer's disease synergistic with the APOE ε4 allele.

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Volume 4, No. 3
March 2021
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