Newest Articles
Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cellsThis study provides evidence that exogenous proteinaceous seeds can induce protein aggregates that sequester stress granule components independent of stress granule assembly.
Dietary restriction induces posttranscriptional regulation of longevity genesBy modulating posttranscriptional processes, including RNA editing, miRNA biogenesis, and intron retention, dietary restriction enacts some of its pro-longevity benefits in Caenorhabditis elegans through posttranscriptional regulation of gene expression.
The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugsThis study shows that the proteomic and transcriptomic states of cancer cells are more predictive of drug sensitivity than genomic markers for most drugs, both within and across tumor types.
Human organotypic brain slice culture: a novel framework for environmental research in neuro-oncologyTherapeutically resected, adult brain segments were maintained and characterized for an extended period to study glioblastoma progression and treatment in its almost natural environment.
Inhibition of host NOX1 blocks tumor growth and enhances checkpoint inhibitor–based immunotherapyBlocking NOX1 with the novel small molecule inhibitor GKT771 inhibits tumor growth in mice by targeting tumor lymph/angiogenesis and promoting antitumor immune cells recruitment. GKT771 emerges as a novel and promising anticancer drug worth translating into the clinics.
Assembly mechanisms of the bacterial cytoskeletal protein FilPFilP is a coiled-coil protein that self-assembles into striated filaments and meshwork that shares structural and biochemical characteristics with metazoan intermediate filaments.
Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosisThis study reports an unexpected role of late endosome–lysosome fusion in early endosome-to-Golgi trafficking of Shiga toxins and identifies tamoxifen to be a potent inhibitor of Shiga toxicosis.
Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesisThe NOTCH pathway, in concert with TNFa, restrains adipogenesis of muscle fibro-adipogenic progenitors (FAPs). Dystrophin-deficient FAPs are less sensitive to NOTCH anti-adipogenic signals, thus explaining why fat infiltrations are solely observed in the muscles of dystrophic individuals.
An unusual and vital protein with guanylate cyclase and P4-ATPase domains in a pathogenic protistToxoplasma gondii harbors an alveolate-specific guanylate cyclase linked to P-type ATPase motifs, which is an essential actuator of cGMP-dependent gliding motility, egress, and invasion during acute infection.
Expression of a constitutively active human STING mutant in hematopoietic cells produces an Ifnar1-dependent vasculopathy in miceTransgenic expression of a mutant hSTING cDNA under the control of the Vav1 gene promoter leads to a vasculopathy similar to that of the interferonopathy, STING-associated vasculopathy of infancy.
