Newest Articles
RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levelsThe work highlights the link between dysfunction of the RNA exosome, ribosome biogenesis, p53-dependent signalling, and apoptosis. Pontocerebellar hypoplasia caused by mutations of the exosome subunits could be classified as a ribosomopathy.
Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cellsThis comprehensive study identifies multiple sclerosis risk expression quantitative trait loci in purified immune cell types.
Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondriaA novel, machine-learning approach to quantify cristae density and architecture in live-cell super-resolution imaging characterizes the ultrastructural parameters of individual mitochondria over time.
Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progressionThis study reports a mechanism of mitochondrial ATP generation whereby EMT-inducer Snail controls ACC2 abundance and subsequent fatty acid oxidation to support cancer survival under starvation conditions.
Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type CThree independent yeast genetic screens were performed identifying proteins and pathways contributing to the pathogenesis of NPC disease and suggesting new therapeutic avenues.
Genetic targeting of neurogenic precursors in the adult forebrain ventricular epitheliumIn vivo evidence for precursors that produce neurons independent of neurosphere-forming neural stem cells suggests the adult forebrain, like the developing brain, has two distinct neurogenic pathways.
Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatusThe mutation P88L in subunit HapE of the CCAAT transcription factor causes resistance of Aspergillus fumigatus to azole drugs due to altered binding, bending, and transcription of target promoters.
STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancersThis work highlights the degradation of STAG1 and inhibition of its interaction with cohesin as promising therapeutic strategies for exploiting synthetic lethality to treat STAG2-mutated tumors and lays the groundwork for the discovery of STAG1-directed small molecules.
Lipid-associated PML structures assemble nuclear lipid droplets containing CCTα and Lipin1PML proteins assemble into noncanonical lipid-associated PML structures (LAPS) on nuclear lipid droplets, which recruit CCTα and Lipin1 for the synthesis of phosphatidylcholine and triacylglycerol.
Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancerEngaging the immunoproteasome helps maintain proteostasis during TNBC development, but ultimately leads to increased immune visibility and favorable prognosis. Assessing i-proteasome expression could augment the prognostic and/or predictive value of TILs assessment in diagnostic practice.
