Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subjects
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research

User menu

  • My alerts

Search

  • Advanced search
Life Science Alliance
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research
  • My alerts
Life Science Alliance

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subjects
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Follow lsa Template on Twitter

Newest Articles

  • FIREWORKS: a bottom-up approach to integrative coessentiality network analysis
    Open Access
    FIREWORKS: a bottom-up approach to integrative coessentiality network analysis

    David R Amici, Jasen M Jackson, Mihai I Truica, Roger S Smith, Sarki A Abdulkadir, Marc L Mendillo

    David R Amici ... Marc L Mendillo

    Published 16 December 2020

    A tool to create bias-adjusted coessentiality networks reveals functional relationships between genes, context-specific rewiring of genetic networks, determinants of essentiality, and therapeutic targets for challenging proteins.

  • Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in <em>Drosophila</em>
    Open Access
    Degradation of arouser by endosomal microautophagy is essential for adaptation to starvation in Drosophila

    Anne-Claire Jacomin, Raksha Gohel, Zunoon Hussain, Agnes Varga, Tamas Maruzs, Mark Eddison, Margaux Sica, Ashish Jain, Kevin G Moffat, Terje Johansen, Andreas Jenny, Gabor Juhasz, Ioannis P Nezis

    Anne-Claire Jacomin ... Ioannis P Nezis

    Published 14 December 2020

    Drosophila EPS8-family protein Arouser is constitutively degraded by endosomal microautophagy; its stabilisation upon starvation is essential to the animal adaptation and survival.

  • Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK–driven lymphomagenesis
    Open Access
    Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK–driven lymphomagenesis

    Elisa Redl, Raheleh Sheibani-Tezerji, Crhistian de Jesus Cardona, Patricia Hamminger, Gerald Timelthaler, Melanie Rosalia Hassler, Maša Zrimšek, Sabine Lagger, Thomas Dillinger, Lorena Hofbauer, Kristina Draganić, Andreas Tiefenbacher, Michael Kothmayer, Charles H Dietz, Bernard H Ramsahoye, Lukas Kenner, Christoph Bock, Christian Seiser, Wilfried Ellmeier, Gabriele Schweikert, Gerda Egger

    Elisa Redl ... Gerda Egger

    Published 11 December 2020

    NPM-ALK–driven lymphoma in mice is dependent on MYC signaling and epigenomic reprogramming via DNA methyltransferases, resulting in heterogenous DNA methylation signatures reminiscent of human lymphoma.

  • Sustained <em>Helicobacter pylori</em> infection accelerates gastric dysplasia in a mouse model
    Open Access
    Sustained Helicobacter pylori infection accelerates gastric dysplasia in a mouse model

    Valerie P O’Brien, Amanda L Koehne, Julien Dubrulle, Armando E Rodriguez, Christina K Leverich, V Paul Kong, Jean S Campbell, Robert H Pierce, James R Goldenring, Eunyoung Choi, Nina R Salama

    Valerie P O’Brien ... Nina R Salama

    Published 11 December 2020

    Hp infection was found to alter metaplasia and accelerate dysplasia in mice. Thus, Hp can promote gastric preneoplastic progression, in addition to its known role in initiating chronic inflammation.

  • ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes
    Open Access
    ESI mutagenesis: a one-step method for introducing mutations into bacterial artificial chromosomes

    Arnaud Rondelet, Andrei Pozniakovsky, Devika Namboodiri, Richard Cardoso da Silva, Divya Singh, Marit Leuschner, Ina Poser, Andrea Ssykor, Julian Berlitz, Nadine Schmidt, Lea Röhder, Gerben Vader, Anthony A Hyman, Alexander W Bird

    Arnaud Rondelet ... Alexander W Bird

    Published 8 December 2020

    A simple and efficient recombineering-based method for introducing point mutations into bacterial artificial chromosomes using an artificial intron cassette.

  • SCF<sup>Cdc4</sup> ubiquitin ligase regulates synaptonemal complex formation during meiosis
    Open Access
    SCFCdc4 ubiquitin ligase regulates synaptonemal complex formation during meiosis

    Zhihui Zhu, Mohammad Bani Ismail, Miki Shinohara, Akira Shinohara

    Zhihui Zhu ... Akira Shinohara

    Published 8 December 2020

    During meiosis, homologous chromosomes pair to form the synaptonemal complex (SC). This study showed that SCFCdc4 ubiquitin ligase is required for and works with Pch2 AAA+ ATPase for SC assembly.

  • Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies
    Open Access
    Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies

    Merav Cohen, Amir Giladi, Catarina Raposo, Mor Zada, Baoguo Li, Julia Ruckh, Aleksandra Deczkowska, Boaz Mohar, Ravid Shechter, Rachel G Lichtenstein, Ido Amit, Michal Schwartz

    Merav Cohen ... Michal Schwartz

    Published 4 December 2020

    We found that acute insult to the central nervous system induces the formation of lymphocyte aggregates reminiscent of tertiary lymphoid structures within the spinal cord meninges. Unlike draining CNS-cervical lymph nodes, meningeal lymphocytes are locally activated during neuro-inflammtion and neurodegeneration.

  • Loss of <em>Jag1</em> cooperates with oncogenic <em>Kras</em> to induce pancreatic cystic neoplasms
    Open Access
    Loss of Jag1 cooperates with oncogenic Kras to induce pancreatic cystic neoplasms

    Wen-Cheng Chung, Lavanya Challagundla, Yunyun Zhou, Min Li, Azeddine Atfi, Keli Xu

    Wen-Cheng Chung ... Keli Xu

    Published 2 December 2020

    Jag1 functions as a tumor suppressor in delaying pancreatic cancer precursor, while at the same time, promotes a phenotypic switch from benign cystic lesions to invasive carcinoma of the pancreas.

  • Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome
    Open Access
    Single-cell RNA sequencing of human breast tumour-infiltrating immune cells reveals a γδ T-cell subtype associated with good clinical outcome

    Katerina Boufea, Víctor González-Huici, Marcus Lindberg, Stefan Symeonides, Olga Oikonomidou, Nizar N Batada

    Katerina Boufea ... Nizar N Batada

    Published 2 December 2020

    Single-cell sequencing of γδ-T cells from human blood and tumours revealed novel markers of subtypes with distinct effector functions and a subtype that is associated with favourable clinical outcome.

  • Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells
    Open Access
    Wnt10b-GSK3β–dependent Wnt/STOP signaling prevents aneuploidy in human somatic cells

    Yu-Chih Lin, Alexander Haas, Anja Bufe, Sabnam Parbin, Magdalena Hennecke, Oksana Voloshanenko, Julia Gross, Michael Boutros, Sergio P Acebron, Holger Bastians

    Yu-Chih Lin ... Holger Bastians

    Published 30 November 2020

    Autocrine Wnt10b signaling ensures proper mitotic microtubule polymerization and faithful chromosome segregation.

Pages

  • Previous
  • Next
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 7
  • 8
  • 9
  • …
  • 42
Issue Cover

Current Issue

Volume 3, No. 12
December 2020
  • Table of Contents
  • Cover (PDF)
  • About the Cover
  • Masthead (PDF)
Sign up for alerts
  • Most Read
Loading
  • SOCS1 regulates immunotherapy in NSCLC
  • TMPRSS2 and furin activate SARS-CoV-2
  • γδ T-cell single-cell RNA-seq
  • Brown preadipocyte heterogeneity
  • Predicting cells position from single-cell transcriptomics
More...
Advertisement

EMBO Press LogoRockefeller University Press LogoCold Spring Harbor Logo

Content

  • Home
  • Newest Articles
  • Current Issue
  • Archive
  • Subject Collections

For Authors

  • Submit a Manuscript
  • Author Guidelines
  • License, copyright, Fee

Other Services

  • Alerts
  • Twitter
  • RSS Feeds

More Information

  • Editors & Staff
  • Reviewer Guidelines
  • Feedback
  • Licensing and Reuse
  • Privacy Policy

ISSN: 2575-1077
© 2021 Life Science Alliance LLC

Life Science Alliance is registered as a trademark in the U.S. Patent and Trade Mark Office and in the European Union Intellectual Property Office.