Newest Articles
BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cellsAlthough pluripotent cells lack circadian oscillations, this study reveals a novel function of the master circadian regulator BMAL1 in metabolism and early differentiation of embryonic stem cells.
Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in miceWild-type Vav1 and mutant K-Ras synergistically accelerate pancreatic acinar-to-ductal metaplasia (ADM), thus leading to pancreatic ductal adenocarcinoma (PDAC), depending on Vav1’s activity as a GEF for Rac1.
Dynamic changes in the regulatory T-cell heterogeneity and function by murine IL-2 muteinSingle-cell RNA-seq analysis reveals that IL-2 mutein treatment expands multiple sub-states of regulatory T cells with superior suppressive function in mice.
Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by BaxMfn2 CMT2A–associated variants located proximal to the hinge connecting its two extended helical bundles have impaired GTP-dependent assembly and mitochondrial fusion activity, which are both improved by cytosolic Bax.
The CCR4–NOT complex maintains liver homeostasis through mRNA deadenylationThe CCR4–NOT complex maintains liver homeostasis by fine-tuning levels of mRNAs, including those for transcription factors, cell cycle regulators, DNA damage response proteins, and liver function–related molecules.
CDKL3 promotes osteosarcoma progression by activating Akt/PKBThis study demonstrates that CDKL3 regulates Akt activation and its downstream targets to promote OS progression, creating a therapeutically targetable vulnerability in treatment of OS.
Genetic and molecular characterization of multicomponent resistance of Pseudomonas against allicinA pseudomonad isolated from garlic has multiple copies of genes on three genomic islands that confer resistance to allicin, a secondary plant product and defense substance that causes disulfide stress.
Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do notGenetic differences between C57BL/6 substrains lead to different cardiovascular traits; a null mutation in Mylk3 likely causes cardiomyopathy in C57BL/6N mice, whereas C57BL/6J Nnt-null mice do not develop cardiomyopathy.
Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG functionThis work combines the use of an inducible Cre recombinase and different lox sites to simultaneously create multiple allelic replacements. We show that an essential malarial cGMP-dependent protein kinase functions exclusively during the release of the parasite from its host cell.
A novel class of polymorphic toxins in BacteroidetesBacteria often use toxins to mediate their interaction with the environment. This study reveals a new class of polymorphic toxins, which contain an N-terminal TANFOR domain, in Bacteroidetes.
